Abstract: A refueling assembly of an engine is provided. The refueling assembly includes a housing, a door positioned within the housing and a flow guide positioned within the housing and downstream of the door including an inlet in fluidic communication with the door, an outlet to flow fuel into a downstream filler pipe in fluidic communication with a fuel tank during a refueling operation, a planar nozzle seating section receiving a fuel nozzle during the refueling operation, and a contraction section positioned downstream of the planar nozzle seating section.

Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

Abstract: The present invention provides ?-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

Abstract: An alternative fuel vehicle having a fuel economy control module with associated logic that allows the vehicle to operate in a fuel economy mode based on a desired fuel economy preference. The fuel economy control logic is in electrical communication with a vehicle system controller (VSC) and may be integrally formed as a sub-module within the VSC. A fuel economy control switch controlled by the fuel economy control logic toggles between an on and an off position to enable or disable a fuel economy mode. A fuel economy control selector allows a user to select a desired fuel economy mode preference once the fuel economy control switch is on. The fuel economy mode selected represents a predefined desired fuel economy preference such as a distance per amount of fuel consumed, or alternatively, a percentage of a balance between a fuel economy operation and a fuel performance operation.

Abstract: An alternative fuel vehicle having a fuel economy control module with associated logic that allows the vehicle to operate in a fuel economy mode based on a desired fuel economy preference. The fuel economy control logic is in electrical communication with a vehicle system controller (VSC) and may be integrally formed as a sub-module within the VSC. A fuel economy control switch controlled by the fuel economy control logic toggles between an on and an off position to enable or disable a fuel economy mode. A fuel economy control selector allows a user to select a desired fuel economy mode preference once the fuel economy control switch is on. The fuel economy mode selected represents a predefined desired fuel economy preference such as a distance per amount of fuel consumed, or alternatively, a percentage of a balance between a fuel economy operation and a fuel performance operation.

Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

Abstract: The present invention provides ?-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

Abstract: The present invention provides &bgr;-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

Abstract: A gas generator utilizes two segregated propellant container/combustion chambers, each having a plurality of nonazide propellant grains therein, and each having an igniter for separately igniting the propellant grains located within the respective chambers. A perforated insulating tube disposed between the two chambers precludes flame front and thermal propagation from one chamber to another, thus preventing redeployment of an activated airbag. Alternatively, a gas generator may contain two separate inflator subassemblies insulated to prevent heat conduction from one subassembly to another.

Abstract: A gas generator utilizes two segregated propellant container/combustion chambers, each having a plurality of nonazide propellant grains therein, and each having an igniter for separately igniting the propellant grains located within the respective chambers. An insulating disc disposed between the two chambers precludes flame front and thermal propagation from one chamber to another, thus preventing redeployment of an activated airbag.

Abstract: A solid propellant gas generator incorporates staged gas cooling and filtration so as to generate cool, clean gases having a composition suitable for use in an automobile airbag inflator. Carbon yarn is used as a lightweight primary heat sink within the filter thereby increasing the dimensional stability of the gas generator.

Abstract: A system for supplying molten thermoplastic material to a dispenser comprises a hopper for storing the thermoplastic material. A heating grid is associated with the hopper for heating and melting the thermoplastic material. A reservoir block receives melted material from the grid. The reservoir block includes a reservoir into which the melted material flows from the grid. A manifold and pump assembly is connected to the reservoir block for receiving material from the manifold block and pumping the material to a dispenser. A valve and filter assembly is mounted in the reservoir block. The valve and filter assembly includes a valve member capable of moving between an open position and a closed position for blocking the flow the material through the reservoir block, and includes a filter member for filtering material, the filter being removable to clean the filter.

Abstract: A solid propellant gas generator incorporating staged gas cooling and filtration so as to generate cool, clean gasses having a composition suitable for use as an automobile airbag inflator. An intermediate cooling and filtration stage consists of aluminum beads that function as both a filter and heat sink.

Abstract: A solid propellant gas generator incorporates staged gas cooling and filtration so as to generate cool, clean gasses having a composition suitable for use in an automobile airbag inflator. Ceramic foam balls are used as a primary heat sink within the filter thereby increasing the dimensional stability of the gas generator.

Abstract: A system for supplying melted thermoplastic material to a dispenser comprises a hopper for storing solid thermoplastic material. The hopper has interior side walls and an outlet. A reservoir block is located below the hopper. The reservoir block includes a reservoir into which melted material may flow from the hopper. A manifold and pump assembly is connected to the reservoir block for receiving material from the reservoir and pumping the material to a dispenser. A heating grid at the outlet of the hopper heats and melts the solid thermoplastic material in the hopper. The grid comprises a block which is spaced from the interior sidewalls of the hopper. The grid is thus thermally isolated from the exterior of the system resulting in more efficient heating of the material.

Abstract: A system for supplying molten thermoplastic material to a dispenser through a supply hose comprises a hopper for storing the thermoplastic material. A heating grid associated with the hopper heats and melts the thermoplastic material. A reservoir block receives the melted material from the grid. The reservoir block includes a reservoir into which the melted material flows from the grid. A manifold assembly is supported below the reservoir block for receiving material from the reservoir.

Abstract: A system for supplying melted thermoplastic material to a dispenser comprises a hopper for storing the thermoplastic material, the hopper having an outlet. A heating grid is at the outlet of the hopper for heating and melting the thermoplastic material. A reservoir is provided into which the melted material flows from the grid. A manifold assembly is connected to the reservoir. The melted material flows into the manifold assembly from the reservoir. The manifold assembly includes connections for supplying the material to a dispenser. The manifold assembly also includes a pump cavity. A pump is mounted in the pump cavity and is capable of being removed from the pump cavity. A drive assembly is connected to drive the pump. A movable carriage supports the drive assembly. The carriage is capable of movement toward and away from the manifold assembly to remove the pump from the cavity and to replace the pump into the cavity.

Abstract: A solid propellant gas generator incorporating staged gas cooling and filtration so as to generate cool, clean gasses having a composition suitable for use as an automobile airbag inflator. An intermediate cooling and filtration stage consists of aluminum beads that function as both a filter and heat sink.

Abstract: A system for supplying melted thermoplastic material to a dispenser a hopper, a heating grid, and a reservoir block providing a reservoir. A support harness is attached to the bottom of the reservoir block. A manifold assembly is supported in the harness below the reservoir block for receiving material from the reservoir. The manifold assembly includes a pump for pumping the material to the dispenser. The manifold assembly is capable of moving vertically within the harness between an upper position in engagement with the reservoir block and a lower position, and the manifold assembly is capable of horizontal movement with respect to the support harness when it is in the lower position, so that the manifold assembly slides horizontally in and out of the support harness. A lifting mechanism connected to the support harness moves the manifold assembly vertically within the harness.