Abstract: The current invention relates to ionic liquid preparation and their application in organic synthesis. More specifically, the present invention relates to the quinoline based ionic liquids having fluoride counter anion and their applications in click chemistry, Knoevenagel condensation to 1,2,5,6-tetrahydronicotinonitrile (12), and pyrazol (15) formation.

Abstract: The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging <1.0-2.9 ?g/mL against IL-2. Studies on innate immune response revealed that compounds 2, 8, 9, and 10 have significant suppressive effect on ROS production with an IC50 values 1.9, <1, 3.7 and 1.1 ?g/mL, respectively. The LPS-induced nitrites in J774 macrophages cell line was inhibited by 4, 8, 9, and 18 at a concentration of 25 ?g/mL (56-91%). In addition compounds 5, 8, 12, and 18 showed potent suppression on interleukin 4 (IL-4), particularly 9 (IC50<1 ?g/mL). No cytotoxicity was found except for compound 9 and 18 (11.4 and 10.4 ?g/mL IC50), respectively.

Abstract: The present invention relates to the compound N-4-nitrophenyl-N?-4?-nitrophenylurea as a urease and ?-chymotrypsin (anti HCV) enzyme inhibitory drug named “Urchym”. N-4-nitrophenyl-N?-4?-nitrophenylurea is prepared and screened for their urease and ?-chymotrypsin inhibition effects, the said compound, showed strong urease inhibition (IC50=1.25 ?M). We found, that the same compound is also an efficient ?-chymotrypsin inhibitor having an IC50 value of 3.15 ?M.