Patents by Inventor Shahriar Mobashery

Shahriar Mobashery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminoglycosides as antibiotics
    Patent number: 7759482
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminoglycosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: July 20, 2010
    Assignee: Wayne State University
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS
    Publication number: 20090209615
    Abstract: The invention provides methods to treat neurological disorders, opthalmological disorders, or a combination thereof by administering a compound that inhibits MMPs. A compound that inhibits MMPs is represented by the compound of formula (I) shown herein.
    Type: Application
    Filed: September 27, 2005
    Publication date: August 20, 2009
    Inventors: Stuart Lipton, Alex Strongin, Shahriar Mobashery, Zezong Gu
  • Inhibitors of Matrix Metallaproteinases
    Publication number: 20090005420
    Abstract: The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
    Type: Application
    Filed: May 19, 2006
    Publication date: January 1, 2009
    Inventors: Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
  • AMINOGLYCOSIDES AS ANTIBIOTICS
    Publication number: 20070203081
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminoglycosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Application
    Filed: May 2, 2007
    Publication date: August 30, 2007
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • Aminoglycosides as antibiotics
    Patent number: 7220727
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 22, 2007
    Assignee: Wayne State University
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • Inhibitors of matrix metalloproteinases
    Patent number: 7144917
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: December 5, 2006
    Assignee: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Aminoglycosides as antibiotics
    Publication number: 20050171035
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Application
    Filed: November 1, 2001
    Publication date: August 4, 2005
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • Inhibitors of matrix metalloproteinases
    Publication number: 20040127478
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 1, 2004
    Applicant: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Inhibitors of matrix metallaproteinases
    Patent number: 6703415
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: March 9, 2004
    Assignee: Wayne State University
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Inhibitors of matrix metallaproteinases
    Publication number: 20020037916
    Abstract: The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloproteinase in vivo or in vitro; and a method for imaging a tumor in vivo or in vitro.
    Type: Application
    Filed: October 3, 2001
    Publication date: March 28, 2002
    Inventors: Shahriar Mobashery, Rafael Fridman
  • Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity
    Patent number: 5286893
    Abstract: Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R.sub.3. The enzyme deprotonates the alpha --CH.sub.2 group and then the intermediate compound forms a covalent bond with enzymic residue in the active site, resulting in irreversible inactivation of the enzyme. The compounds are particularly inactivators of renal dipeptidases.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: February 15, 1994
    Assignee: Board of Governors of Wayne State University
    Inventor: Shahriar Mobashery
  • Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity
    Patent number: 5238930
    Abstract: Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R.sub.3. The enzyme deprotonates the alpha--CH.sub.2 group and then the intermediate compound forms a covalent bond with enzymic residue in the active site, resulting in irreversible inactivation of the enzyme. The compounds are particularly inactivators of renal dipeptidases.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: August 24, 1993
    Assignee: Board of Governors of Wayne State University
    Inventor: Shahriar Mobashery
  • Method for inactivating dehydropepidase activity irreversibly with alkenoic acid compounds
    Patent number: 5112751
    Abstract: Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R.sub.3. The enzyme deprotonates the alpha-CH.sub.2 group and then the intermediate compound forms a covalent bond with enzymic residue in the active site, resulting in irreversible inactivation of the enzyme. The compounds are particularly inactivators of renal dipeptidases.
    Type: Grant
    Filed: February 6, 1991
    Date of Patent: May 12, 1992
    Assignee: Board of Governors of Wayne State University
    Inventor: Shahriar Mobashery