Patents by Inventor Shahriar Taremi

Shahriar Taremi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERK2 CRYSTALS
    Publication number: 20080081360
    Abstract: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
    Type: Application
    Filed: October 17, 2007
    Publication date: April 3, 2008
    Inventors: Jessie English, Thierry Fischmann, Thomas Hesson, Alan Hruza, Weihong Jin, Paul Reichert, Catherine Smith, Shahriar Taremi
  • Catalytic domain of ADAM33 and methods of use thereof
    Publication number: 20070031401
    Abstract: The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
    Type: Application
    Filed: October 2, 2006
    Publication date: February 8, 2007
    Inventors: Wenyan Wang, Hung Le, Jian-Jun Liu, Vincent Madison, Winifred Prosise, Shahriar Taremi, Li Xiao, Jun Zou
  • ERK2 crystals
    Publication number: 20060088924
    Abstract: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 27, 2006
    Inventors: Jessie English, Thierry Fischmann, Thomas Hesson, Alan Hruza, Weihong Jin, Paul Reichert, Catherine Smith, Shahriar Taremi
  • Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof
    Publication number: 20050037383
    Abstract: The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
    Type: Application
    Filed: April 9, 2004
    Publication date: February 17, 2005
    Inventors: Shahriar Taremi, Gaolian Xie, Thomas Hesson, Jose Duca, Corey Strickland, William Windsor, Vincent Madison, Rumin Zhang, Paul Reichert