Abstract: A plasmonic device including a support layer extending along a first direction and a second direction, an insulating layer on the support layer, and a plasmonic layer on the insulating layer and defining a cavity extending along the first direction, the cavity having a three-dimensionally (3D) tapered structure and being configured to propagate an electromagnetic field along the first direction and to concentrate the electromagnetic field at a tip of the cavity, wherein the support layer, the insulating layer, and the plasmonic layer define an opening therein, the opening being at the tip of the cavity and being configured to pass-through target molecules of a solution present on the plasmonic layer.

Abstract: The disclosure is directed to a system and a method for biosignal detection, the method including emitting an electromagnetic spectral emission, including polarized light, that is reflected on a surface, collecting attributes from the reflected electromagnetic spectral emission, calculating Stokes parameters based on the collected attributes, determining at least one signal based on the Stokes parameters, and analyzing the at least one signal to estimate health-related information, wherein the collected attributes comprise at least one of a light intensity of a predetermined polarization state, a light intensity for a wavelength range, and a light intensity for multiple pixels

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.