Abstract: Transgenic adipocytes that express and secrete a therapeutic biologic agent (TBA) are provided. Also provided are methods for producing these transgenic adipocytes and methods for using these transgenic adipocytes to treat a condition in a subject.

Abstract: In part, the present disclosure relates methods for treating heterotopic ossification or one or more complications of heterotopic ossification. In particular, the disclosure provided methods for treating heterotopic ossification by administering to a patient in need thereof one or more TGF? antagonists, optionally in combination with one or more additional active agents or supportive therapies for treating heterotopic ossification. For example, in some embodiments, the disclosure provided methods for treating heterotopic ossifications by administering to a patient in need thereof an effective amount of a T?RII polypeptide.

Abstract: The invention provides a method of treating heterotopic ossification in a subject in need thereof. The method comprises administering a hypoxia inducible factor-1? (Hif-1?) inhibitor to the subject. In various embodiments, the Hif-1? inhibitor is PX-478, rapamycin, or digoxin.

Abstract: The invention provides a method of treating heterotopic ossification in a subject in need thereof. The method comprises administering a hypoxia inducible factor-1? (Hif-1?) inhibitor to the subject. In various embodiments, the Hif-1? inhibitor is PX-478, rapamycin, or digoxin.

Abstract: The invention provides a method of treating heterotopic ossification in a subject in need thereof. The method comprises administering a hypoxia inducible factor-1? (Hif-1?) inhibitor to the subject. In various embodiments, the Hif-1? inhibitor is PX-478, rapamycin, or digoxin.

Abstract: The invention provides a method of treating heterotopic ossification in a subject in need thereof. The method comprises administering a hypoxia inducible factor-1? (Hif-1?) inhibitor to the subject. In various embodiments, the Hif-1? inhibitor is PX-478, rapamycin, or digoxin.

Abstract: A method and system for implementing secure communication in an un-trusted execution environment. The method includes transmitting respective first and second certificates between a first component and a second component, wherein the first certificate and the second certificate are respectively hidden within software code comprising the first component and the second component. A secure communication channel is then generated between the first component and the second component by the second component using a first public key of the first certificate and the first component using a second public key of the second certificate. The identity of the first component is verified by the second component checking the first certificate with respect to a certificate authority. The identity of the second component is verified by the first component checking the second certificate with respect to the certificate authority.

Abstract: A method and apparatus is provided for populating an object-oriented data structure from data stored in a conventional relational database. In particular, a method and apparatus is provided for transforming the results of a complex relational database query such as a join query (i.e., where each row of results from the relational database corresponds to data from multiple tables) into a network of inter-related heterogeneous objects contained an object-oriented data structure. Further, the present invention provides a method and apparatus for more efficiently knitting the relationships between newly created objects in an object-oriented data structure.