Patent number: 9682977
Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.
Type:
Grant
Filed:
December 9, 2014
Date of Patent:
June 20, 2017
Assignee:
GLENMARK PHARMACEUTICALS S.A.
Inventors:
Sanjib Das, Sachin Sundarlal Chaudhari, Abraham Thomas, Shailesh Ramesh Pardeshi, Vishal Govindrao Deshmukh, Prashant Dilip Wadekar, Neelima Khairatkar-Joshi, Daisy Manish Shah, Malini Bajpai
Publication number: 20160326163
Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.
Type:
Application
Filed:
December 9, 2014
Publication date:
November 10, 2016
Inventors:
Sanjib DAS, Sachin Sundarlal CHAUDHARI, Abraham THOMAS, Shailesh Ramesh PARDESHI, Vishal Govindrao DESHMUKH, Prashant Dilip WADEKAR, Neelima KHAIRATKAR-JOSHI, Daisy Manish SHAH, Malini BAJPAI
