Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10406004
    Abstract: A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: September 10, 2019
    Assignee: POLY-MED, INC.
    Inventors: Shalaby W. Shalaby, Kenneth W. Clinkscales, Kenneth David Gray
  • Publication number: 20190167839
    Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
    Type: Application
    Filed: January 22, 2019
    Publication date: June 6, 2019
    Inventors: Shalaby W. Shalaby, Jason Olbrich, Joel T. Corbett
  • Publication number: 20190083222
    Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
    Type: Application
    Filed: September 12, 2018
    Publication date: March 21, 2019
    Applicant: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Michael Scott Taylor, Douglas D. Greene
  • Publication number: 20180296312
    Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
    Type: Application
    Filed: April 28, 2014
    Publication date: October 18, 2018
    Applicant: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
  • Publication number: 20180296735
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Inventor: Shalaby W. Shalaby
  • Patent number: 10098722
    Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: October 16, 2018
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
  • Patent number: 10085826
    Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 2, 2018
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
  • Patent number: 10004833
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Grant
    Filed: November 13, 2016
    Date of Patent: June 26, 2018
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 9884140
    Abstract: A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: February 6, 2018
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Shawn Peniston, Kimberly A. Carpenter
  • Publication number: 20170313808
    Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 2, 2017
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, Michael Aaron Vaughn, David Ingram
  • Patent number: 9687368
    Abstract: Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: June 27, 2017
    Assignee: Medtronic Vascular, Inc.
    Inventors: Kishore Udipi, Peiwen Cheng, Shalaby W. Shalaby, Todd Campbell, Su Ping Lyu
  • Publication number: 20170056564
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Application
    Filed: November 13, 2016
    Publication date: March 2, 2017
    Applicant: POLY-MED, INC.
    Inventor: Shalaby W. Shalaby
  • Patent number: 9566267
    Abstract: Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: February 14, 2017
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas
  • Patent number: 9533001
    Abstract: Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: January 3, 2017
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas, Kenneth David Gray
  • Patent number: 9492593
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: November 15, 2016
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 9457090
    Abstract: Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: October 4, 2016
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, David Ingram, Georgios Hilas, Sheila Nagatomi
  • Patent number: 9446165
    Abstract: Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: September 20, 2016
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M. Lindsey, Scott Taylor, David E. Linden, David R. Ingram
  • Publication number: 20160243292
    Abstract: Radiopaque, iodinated, absorbable polyesters, polyester urethanes, and polyether-ester-urethanes with and without inorganic iodide micro-/nanoparticles dispersed or solubilized therein, and composite inorganic iodide micro-/nanoparticles in an absorbable polyester, polyester-urethane, polyester-ester, or polyether-ester urethane matrix are employed in medical devices and therapeutic compositions.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 25, 2016
    Inventors: Shalaby W. Shalaby, Kenneth David Gray
  • Patent number: 9402932
    Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 2, 2016
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich
  • Publication number: 20160184493
    Abstract: This invention describes a partially absorbable, fiber-reinforced composite in the form of a ring, or a suture-like thread, with modified terminals for use as a controlled delivery system of at least one bioactive agent, wherein said composite comprising an absorbable fiber construct capable of providing time-dependent mechanical properties of a biostable elastomeric matrix containing an absorbable microparticulate ion-exchanger to modulate the release of the bioactive agent(s) for a desired period(s) of time at a specific biological site; this can be a vaginal canal, peritoneal cavity, scrotum, prostate gland, an ear loop or subcutaneous tissue. Such drug delivery systems can be used for the local administration of at least one bioactive agent, including those used as contraceptive, antimicrobial, anti-inflammatory and/or antiviral agents as well as for cancer treatment.
    Type: Application
    Filed: March 9, 2016
    Publication date: June 30, 2016
    Applicant: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby