Patents by Inventor Shalesh Kaushal
Shalesh Kaushal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200188405Abstract: A method for treating choroidal neovascularization in a patient includes administrating as eye drops into the eye of the patient having choroidal neovascularization a therapeutically effective amount of an aqueous ophthalmic composition that is formulated for topical administration as eye drops. The aqueous ophthalmic composition consists essentially of Timolol Maleate at a concentration of about 0.1% to 0.5%, Dorzolamide at a concentration of about 0.5% to 2.5%, Prednisolone at a concentration of about 1.0% to 3.0%, Ketorolac Tromethamine at a concentration of about 0.4% to 1.2%, and sterile water at a concentration of at least about 90.0%.Type: ApplicationFiled: February 25, 2020Publication date: June 18, 2020Inventor: Shalesh KAUSHAL
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Publication number: 20190134051Abstract: An aqueous ophthalmic composition for treating ocular disorders, such as macular degeneration and retinopathy, includes Timolol Maleate at a concentration of about 0.1% to 0.5%, Dorzolamide at a concentration of about 0.5% to 2.5%, Prednisolone Sodium Phosphate at a concentration of about 1.0% to 3.0%, Ketorolac Tromethamine at a concentration of about 0.4% to 1.2%, and sterile water at a concentration of at least about 90.0%.Type: ApplicationFiled: November 1, 2018Publication date: May 9, 2019Inventor: Shalesh KAUSHAL
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Patent number: 9907762Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.Type: GrantFiled: September 4, 2015Date of Patent: March 6, 2018Assignees: UNIVERSITY OF WASHINGTON, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
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Publication number: 20160045453Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.Type: ApplicationFiled: September 4, 2015Publication date: February 18, 2016Inventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
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Patent number: 9149446Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.Type: GrantFiled: August 24, 2011Date of Patent: October 6, 2015Assignees: UNIVERSITY OF WASHINGTON, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
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Patent number: 8512323Abstract: Disclosed are devices and methods for correlating or aligning pre-surgical image(s) with image(s) observed during a surgical procedure to aid in orientation of tissues and devices for performing a surgical procedure. In a preferred embodiment, the invention provides devices and methods for aligning pre-surgical image(s) of optical tissues or structures, e.g., the retina, with real-time images observed or obtained with a slit lamp, or other optical viewing device. The ability of the subject invention to correlate these images can advantageously provide the physician with greater accuracy when administering surgical treatment, such as with a laser, and can significantly reduce surgery time.Type: GrantFiled: September 12, 2007Date of Patent: August 20, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Michael Darnall Furman, Thomas Bryan Demarse, Jennifer Delight Simonotto
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Publication number: 20130072443Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.Type: ApplicationFiled: September 14, 2012Publication date: March 21, 2013Applicants: Regents of the University of Minnesota, University of WashingtonInventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
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Patent number: 8150506Abstract: The subject invention utilizes the characteristics of in vivo tissue impedances to provide an embodiment of a retinal rake capable of providing a visible and/or preferably an audible signal to a surgeon that more clearly indicates which type of tissue(s) is in contact with the retinal rake. A preferred embodiment comprises a handheld, battery operated retinal rake having two electrodes, wherein at least one electrode is the modified retinal rake. Upon contact with different optical tissues, e.g., epiretinal membranes, retinal tissue, vitreous humor, etc., the electrodes detect varying impedances which are translated by onboard circuitry into various signals that indicate what type of tissue, fluid, structure, etc. is in contact with the retinal rake.Type: GrantFiled: September 12, 2007Date of Patent: April 3, 2012Assignee: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Michael Darnall Furman, Jennifer Delight Simonotto, Abraham Miliotis
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Publication number: 20120041073Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.Type: ApplicationFiled: August 24, 2011Publication date: February 16, 2012Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, UNIVERSITY OF WASHINGTONInventors: KRZYSZTOF PALCZEWSKI, SHALESH KAUSHAL, VLADIMIR KUKSA, SYED M. NOORWEZ
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Publication number: 20110218143Abstract: The invention generally provides compositions and methods for the repair or regeneration of a tissue or organ in need thereof.Type: ApplicationFiled: November 20, 2008Publication date: September 8, 2011Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATIONInventors: Shalesh Kaushal, Mani Annamalai
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Publication number: 20100204093Abstract: The present invention generally provides therapeutic compositions and methods for treating a disease, disorder, or injury characterized by a deficiency in cell number. The method involves inducing a heat shock response in tissue or organ effected by disease and recruiting stem cells to repair or regenerate the disease-effected tissue.Type: ApplicationFiled: July 27, 2007Publication date: August 12, 2010Applicant: University of Florida Research Foundation, IncInventors: Shalesh Kaushal, Maria G. Grant
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Publication number: 20100104644Abstract: Methods are disclosed for treating or preventing ophthalmic conditions related to a toxic visual cycle product. Compounds and compositions useful in these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said the therapeutic and prophylactic methods of the invention.Type: ApplicationFiled: July 27, 2007Publication date: April 29, 2010Applicant: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Syed Mohammed Noorwez
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Publication number: 20100087474Abstract: The invention features compositions and methods that are useful for treating or preventing a protein conformation disease in a subject by enhancing the degradation of misfolded proteins in vivo.Type: ApplicationFiled: April 27, 2006Publication date: April 8, 2010Applicant: UNIVERSITY OF FLORIDAInventors: Shalesh Kaushal, Ritu Malhotra, William A. Dunn
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Publication number: 20100068141Abstract: The invention generally provides methods for recruiting stem cells to an ocular tissue. The methods involve inducing heat shock in the ocular tissue using a subthreshold laser and/or an agent. In some embodiments, the heat shock is induced following the administration of an agent that mobilizes HSCs.Type: ApplicationFiled: July 27, 2006Publication date: March 18, 2010Applicant: UNIVERSITY OF FLORIDAInventors: Shalesh Kaushal, Maria G. Grant
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Publication number: 20100063498Abstract: The subject invention utilizes the characteristics of in vivo tissue impedances to provide an embodiment of a retinal rake capable of providing a visible and/or preferably an audible signal to a surgeon that more clearly indicates which type of tissue(s) is in contact with the retinal rake. A preferred embodiment comprises a handheld, battery operated retinal rake having two electrodes, wherein at least one electrode is the modified retinal rake. Upon contact with different optical tissues, e.g., epiretinal membranes, retinal tissue, vitreous humor, etc., the electrodes detect varying impedances which are translated by onboard circuitry into various signals that indicate what type of tissue, fluid, structure, etc. is in contact with the retinal rake.Type: ApplicationFiled: September 12, 2007Publication date: March 11, 2010Applicant: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Michael Darnall Furman, Jennifer Delight Simonotto, Abraham Miliotis
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Publication number: 20100004156Abstract: The invention features compositions and methods that are useful for treating or preventing a protein conformation disease in a subject by correcting misfolded proteins in vivo. In addition, the invention provides compositions and methods that are useful for expressing a recombinant protein in a biochemically functional conformation.Type: ApplicationFiled: July 27, 2006Publication date: January 7, 2010Inventors: Shalesh Kaushal, Syed Mohammed Noorwez
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Publication number: 20090318911Abstract: Disclosed are devices and methods for correlating or aligning pre-surgical image(s) with image(s) observed during a surgical procedure to aid in orientation of tissues and devices for performing a surgical procedure. In a preferred embodiment, the invention provides devices and methods for aligning pre-surgical image(s) of optical tissues or structures, e.g., the retina, with real-time images observed or obtained with a slit lamp, or other optical viewing device. The ability of the subject invention to correlate these images can advantageously provide the physician with greater accuracy when administering surgical treatment, such as with a laser, and can significantly reduce surgery time.Type: ApplicationFiled: September 12, 2007Publication date: December 24, 2009Inventors: Shalesh Kaushal, Michael Darnall Furman, Thomas Bryan Demarse, Jennifer Delight Simonotto
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Publication number: 20090291919Abstract: Methods are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle during medical procedures that expose the eye to light, most commonly the various forms of ophthalmic surgery. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said treatments.Type: ApplicationFiled: January 21, 2009Publication date: November 26, 2009Applicant: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Syed M. Noorwez
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Publication number: 20090286808Abstract: The present invention provides compositions and methods useful in the treatment and/or prevention of ophthalmic conditions and diseases, such as retinitis pigmentosa, that are dependent upon or related to misfolded opsin proteins in vivo. In addition, screening assays for agents useful in such treatment methods are described.Type: ApplicationFiled: January 21, 2009Publication date: November 19, 2009Applicant: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Syed M. Noorwez, David A. Ostrov
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Publication number: 20040242704Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.Type: ApplicationFiled: March 15, 2004Publication date: December 2, 2004Applicants: University of Washington, TechTransfer - Invention Licensing, Regents of the University of MinnesotaInventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez