Patents by Inventor Shalini Prasad
Shalini Prasad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240081674Abstract: Detection devices for detecting one or more target analytes such as volatile organic compounds (VOCs) may include a base and a sensor module coupleable to the base and including at least one electrochemical sensor, where the electrochemical sensor includes an electrode and an ionic liquid (e.g., room temperature ionic liquid) that is arranged on the electrode and specific to a target analyte. In some variations, at least one cavity specific to the target analyte is formed within the ionic liquid in response to the electrochemical sensor receiving an input signal.Type: ApplicationFiled: March 21, 2023Publication date: March 14, 2024Inventors: Shalini PRASAD, Kordel Kade FRANCE, Ivneet Kaur BANGA, Anirban PAUL
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Patent number: 11926822Abstract: This disclosure relates to compositions and methods for three-dimensional spatial profiling of analytes in a biological sample. The methods include use of a hydrogel comprising one or more polymers that include a phenol moiety, an azide moiety, or an alkyne moiety.Type: GrantFiled: September 22, 2021Date of Patent: March 12, 2024Assignee: 10x Genomics, Inc.Inventors: Shalini Gohil, Eswar Prasad Ramachandran Iyer
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Publication number: 20230408499Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: ApplicationFiled: August 2, 2023Publication date: December 21, 2023Applicants: EnLiSense LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Patent number: 11782055Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: GrantFiled: October 19, 2017Date of Patent: October 10, 2023Assignees: EnLiSense, LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Patent number: 11614419Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.Type: GrantFiled: March 25, 2020Date of Patent: March 28, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Shalini Prasad, Anjan Panneer Selvam
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Publication number: 20210386317Abstract: Detection devices for detecting one or more target analytes such as volatile organic compounds (VOCs) may include a base and a sensor module coupleable to the base and including at least one electrochemical sensor, where the electrochemical sensor includes an electrode and an ionic liquid (e.g., room temperature ionic liquid) that is arranged on the electrode and specific to a target analyte. In some variations, at least one cavity specific to the target analyte is formed within the ionic liquid in response to the electrochemical sensor receiving an input signal.Type: ApplicationFiled: June 10, 2021Publication date: December 16, 2021Inventors: Shalini PRASAD, Kordel Kade FRANCE, Ivneet Kaur BANGA, Anirban PAUL
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Patent number: 11154242Abstract: One aspect of the invention provides a method of determining metal ion levels in the patents due to corrosion and wear processes of the metallic implant in a human or veterinary patient. One embodiment provides a cost effective and patient driven early diagnostic method which has a potential application in orthopedics and dentistry. In one embodiment, the method includes the use of an electrochemical biosensor to detect metal ions or particles in a sample taken from a patient having a metallic implant.Type: GrantFiled: March 11, 2015Date of Patent: October 26, 2021Assignees: Rush University Medical Center, Board of Regents, The University of Texas SystemInventors: Mathew T. Mathew, Shalini Prasad, Markus A. Wimmer, Nadim J. Hallab, Joshua Jacobs
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Publication number: 20210239635Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying a target analyte in a sample using a handheld measuring device.Type: ApplicationFiled: April 21, 2021Publication date: August 5, 2021Inventors: Shalini PRASAD, Anjan PANNEER SELVAM
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Publication number: 20200240939Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.Type: ApplicationFiled: March 25, 2020Publication date: July 30, 2020Inventors: Shalini PRASAD, Anjan PANNEER SELVAM
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Patent number: 10641721Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.Type: GrantFiled: March 6, 2015Date of Patent: May 5, 2020Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Shalini Prasad, Anjan Panneer Selvam
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Publication number: 20190250153Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: ApplicationFiled: October 19, 2017Publication date: August 15, 2019Applicants: EnLiSense, LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Publication number: 20190069818Abstract: A biosensor device includes a porous substrate, where the substrate comprises semiconductor elements functionalized to conjugate with a particular analyte, the semiconductor elements are embedded within at least a portion of the substrate, and the substrate is to absorb fluid capable of carrying the particular analyte. The device further includes two or more electrodes attached to the substrate to correspond to the portion of the substrate, where the portion of the substrate further comprises Room-Temperature Ionic Liquid (RTIL).Type: ApplicationFiled: September 6, 2018Publication date: March 7, 2019Inventors: Shalini Prasad, Sriram Muthukumar
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Patent number: 10006882Abstract: An example biosensor is provided and includes a semiconductor sensing element, a first electrode and a second electrode located on a first plane of the sensing element with a first electric field being applied thereacross, a third electrode located on a second plane of the sensing element parallel to and removed from the first plane with a second electric field being applied across the first electrode and the third electrode perpendicular to the first electric field, and a dielectric substrate having a first portion that constrains a fluid including an analyte on a surface of the sensing element, and a second portion that facilitates dielectric separation of the fluid from the electrodes. The mutually perpendicular electric fields facilitate adjusting a height of a fluid-sensor interface comprising an electrical double layer in the fluid enabling detection and characterization of the analyte.Type: GrantFiled: November 20, 2015Date of Patent: June 26, 2018Assignee: EnLiSense, LLCInventors: Shalini Prasad, Sriram Muthukumar, Anjan Panneer Selvam
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Publication number: 20170014072Abstract: One aspect of the invention provides a method of determining metal ion levels in the patents due to corrosion and wear processes of the metallic implant in a human or veterinary patient. One embodiment provides a cost effective and patient driven early diagnostic method which has a potential application in orthopedics and dentistry. In one embodiment, the method includes the use of an electrochemical biosensor to detect metal ions or particles in a sample taken from a patient having a metallic implant.Type: ApplicationFiled: March 11, 2015Publication date: January 19, 2017Applicants: RUSH UNIVERSITY MEDICAL CENTER, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEMInventors: Mathew T. Mathew, Shalini Prasad, Markus A. Wimmer, Nadim J. Hallab, Joshua Jacobs
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Publication number: 20160146754Abstract: An example biosensor is provided and includes a semiconductor sensing element, a first electrode and a second electrode located on a first plane of the sensing element with a first electric field being applied thereacross, a third electrode located on a second plane of the sensing element parallel to and removed from the first plane with a second electric field being applied across the first electrode and the third electrode perpendicular to the first electric field, and a dielectric substrate having a first portion that constrains a fluid including an analyte on a surface of the sensing element, and a second portion that facilitates dielectric separation of the fluid from the electrodes. The mutually perpendicular electric fields facilitate adjusting a height of a fluid-sensor interface comprising an electrical double layer in the fluid enabling detection and characterization of the analyte.Type: ApplicationFiled: November 20, 2015Publication date: May 26, 2016Inventors: Shalini Prasad, Sriram Muthukumar, Anjan Panneer Selvam
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Patent number: 9222907Abstract: Sensors include nano-porous alumina membranes that are sensitized by immobilization of antibodies in the nano-pores. The nano-membranes can be sensitized to respond to a single target compound, or different portions of the nano-membrane can be differently sensitized. Capture of the target compound can be detected based on a spectral signature associated with electrical conductance in the nano-pores.Type: GrantFiled: April 2, 2013Date of Patent: December 29, 2015Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Portland State UniversityInventors: Shalini Prasad, Ravi Kiran Kondama Reddy
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Publication number: 20150355133Abstract: In some embodiments, the compositions and methods relate to nano-well sensors and methods for using the same to detect target molecules in samples. In some embodiments, the nano-well chip comprises three parts: (a) a solid substrate, (b) a nanoporous nylon membrane situated on the top surface of the solid substrate, and (c) a polymer on top of and surrounding the nano-porous nylon membrane.Type: ApplicationFiled: January 7, 2014Publication date: December 10, 2015Inventor: Shalini PRASAD
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Publication number: 20150276637Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.Type: ApplicationFiled: March 6, 2015Publication date: October 1, 2015Inventors: Shalini PRASAD, Anjan PANNEER SELVAM
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Publication number: 20150114850Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying a target analyte in a sample using a handheld measuring device.Type: ApplicationFiled: July 31, 2014Publication date: April 30, 2015Inventors: Shalini PRASAD, Anjan PANNEER SELVAM
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Publication number: 20140011691Abstract: The invention relates to devices and diagnostic methods using the devices for detecting the presence of neurodegenerative diseases. The device (a “biosensor”) distinguishes between different neurodegenerative diseases and facilitates pre-symptomatic diagnoses.Type: ApplicationFiled: October 26, 2011Publication date: January 9, 2014Inventors: Michael Sierks, Srinath Kasturirangan, Sharareh Emadi, Shalini Prasad