Abstract: The present disclosure provides for a method of treating increased gut permeability, including administering a therapeutically effective amount of a human-derived probiotic to a patient in need thereof. Further provided herein is a method of increasing a patient's metabolism of ethanolamine, including administering a therapeutically effective amount of human derived probiotics to the patient in need thereof. Also provided herein is a pharmaceutical composition, including a first strain of Lactobacillus and a second probiotic strain. The present disclosure also provides for a pharmaceutical composition, including Lactobacillus and an antidiabetic drug. Additionally, provided herein is a pharmaceutical composition, including Lactobacillus and a weight management drug.