Patents by Inventor Shalom Michaeli
Shalom Michaeli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240027558Abstract: Systems and methods for producing an image of a subject with a magnetic resonance imaging (MRI) system. The method includes acquiring first MRI data from the subject using a first coil having a first field of view (FOV), simultaneously with or sequentially with acquiring the first MRI data, acquiring second MRI data from the subject using a second coil having a second FOV that is non-overlapping with the first FOV, and reconstructing images of the subject from the first MRI data and the second MRI data.Type: ApplicationFiled: July 25, 2023Publication date: January 25, 2024Inventors: Silvia Mangia, Shalom Michaeli, Djaudat Idiyatullin, Gregor Adriany, Mikko Kettunen, Michael Garwood, Olli Gröhn
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Patent number: 11474174Abstract: The present disclosure provides a method for using a magnetic resonance system to measure magnetization data from a region of interest in a subject having a spin system that includes at least a first labile spin species and a second labile spin species experiencing chemical exchange. The method includes applying periodic radiofrequency irradiation to the spin system using a frequency swept pulse sequence having frequency and amplitude modulation functions, wherein sweeping a frequency of the RF irradiation together with amplitude modulation generates a magnetic field component having an effective field. The method further includes generating off resonance side bands in a frequency domain positioned adjacent the resonant frequency of the first labile spin species or the second labile spin species by applying the periodic RF irradiation to induce the instantaneous flip of the effective field with periodicity of RF irradiation tuned to the chemical shift difference of the exchanging sites.Type: GrantFiled: August 31, 2020Date of Patent: October 18, 2022Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Shalom Michaeli, Timo Liimatainen, Hanne Laakso, Silvia Mangia
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Publication number: 20210063512Abstract: The present disclosure provides a method for using a magnetic resonance system to measure magnetization data from a region of interest in a subject having a spin system that includes at least a first labile spin species and a second labile spin species experiencing chemical exchange. The method includes applying periodic radiofrequency irradiation to the spin system using a frequency swept pulse sequence having frequency and amplitude modulation functions, wherein sweeping a frequency of the RF irradiation together with amplitude modulation generates a magnetic field component having an effective field. The method further includes generating off resonance side bands in a frequency domain positioned adjacent the resonant frequency of the first labile spin species or the second labile spin species by applying the periodic RF irradiation to induce the instantaneous flip of the effective field with periodicity of RF irradiation tuned to the chemical shift difference of the exchanging sites.Type: ApplicationFiled: August 31, 2020Publication date: March 4, 2021Inventors: Shalom Michaeli, Timo Liimatainen, Hanne Laakso, Silvia Mangia
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Patent number: 10912941Abstract: Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.Type: GrantFiled: January 5, 2018Date of Patent: February 9, 2021Assignee: Regents of the University of MinnesotaInventors: Shalom Michaeli, John T. Vaughan, Silvia Mangia, Lauri Lehto, Matthew Johnson, Julia Slopsema, Olli Gröhn, Gregory F. Molnar
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Patent number: 10821287Abstract: Described here are bioelectric modulation systems and methods for generating rotating or spatially-selective electromagnetic fields. A modulation system includes a multichannel electrode with independently controllable electrode channels that can be operated to generate rotating electromagnetic fields that stimulate cells regardless of their orientation, or to generate spatially-selective electromagnetic fields that preferentially stimulate cells oriented along a particular direction. The bioelectric modulation system may be implemented for stimulation of neurons or other electrically active cells. The bioelectric modulation described here may be used for a variety applications including deep brain stimulation (DBS), spinal cord and vagus nerve stimulation, stimulation of myocardial (heart) tissue, and directional stimulation of muscles.Type: GrantFiled: April 12, 2017Date of Patent: November 3, 2020Assignee: Regents of the University of MinnesotaInventors: Shalom Michaeli, Silvia Mangia, Olli Grohn, Artem Shatillo, Lauri Lehto, Matthew Johnson, Simeng Zhang, Julia Slopsema
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Publication number: 20180185649Abstract: Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.Type: ApplicationFiled: January 5, 2018Publication date: July 5, 2018Inventors: Shalom Michaeli, John T. Vaughan, Silvia Mangia, Lauri Lehto, Matthew Johnson, Julia Slopsema, Olli Gröhn, Gregory F. Molnar
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Publication number: 20170296825Abstract: Described here are bioelectric modulation systems and methods for generating rotating or spatially-selective electromagnetic fields. A modulation system includes a multichannel electrode with independently controllable electrode channels that can be operated to generate rotating electromagnetic fields that stimulate cells regardless of their orientation, or to generate spatially-selective electromagnetic fields that preferentially stimulate cells oriented along a particular direction. The bioelectric modulation system may be implemented for stimulation of neurons or other electrically active cells. The bioelectric modulation described here may be used for a variety applications including deep brain stimulation (DBS), spinal cord and vagus nerve stimulation, stimulation of myocardial (heart) tissue, and directional stimulation of muscles.Type: ApplicationFiled: April 12, 2017Publication date: October 19, 2017Inventors: SHALOM MICHAELI, SILVIA MANGIA, OLLI GROHN, ARTEM SHATILLO, LAURI LEHTO, MATTHEW JOHNSON, SIMENG ZHANG, JULIA SLOPSEMA
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Patent number: 9341692Abstract: A method includes acquiring a signal intensity from a spin system after applying the radio frequency preparation pulses prior to the imaging readout or spectroscopic localization, and acquiring signal intensity starting with magnetization initially rotated to a certain angle by applying an initial pulse before the preparation scheme, and processing the data to generate an image or spectra corresponding to the spin system. The imaging or spectroscopy sequence is configured to provide data based on magnetization transfer or an off-resonance effect.Type: GrantFiled: April 14, 2011Date of Patent: May 17, 2016Assignee: Regents of the University of MinnesotaInventors: Silvia Mangia, Shalom Michaeli, Michael G. Garwood
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Patent number: 9222999Abstract: A system includes a driving module, a processor, and a readout module. The driving module is configured to apply a perturbation to a sample. The processor is configured to define a plurality of different rotating frames relative to the perturbation, wherein each frame has a corresponding fictitious field. The readout module is coupled to the processor and is configured to generate an output based on relaxation of the sample as a function of the perturbation.Type: GrantFiled: April 9, 2012Date of Patent: December 29, 2015Assignee: Regents of the University of MinnesotaInventors: Shalom Michaeli, Silvia Mangia, Dennis J. Sorce, Michael G. Garwood, Timo Liimatainen
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Publication number: 20130069649Abstract: A method includes acquiring a signal intensity from a spin system after applying the radio frequency preparation pulses prior to the imaging readout or spectroscopic localization, and acquiring signal intensity starting with magnetization initially rotated to a certain angle by applying an initial pulse before the preparation scheme, and processing the data to generate an image or spectra corresponding to the spin system. The imaging or spectroscopy sequence is configured to provide data based on magnetization transfer or an off-resonance effect.Type: ApplicationFiled: April 14, 2011Publication date: March 21, 2013Applicant: Regents of the University of MinnesotaInventors: Silvia Mangia, Shalom Michaeli, Michael G. Garwood
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Publication number: 20120286780Abstract: A system includes a driving module, a processor, and a readout module. The driving module is configured to apply a perturbation to a sample. The processor is configured to define a plurality of different rotating frames relative to the perturbation, wherein each frame has a corresponding fictitious field. The readout module is coupled to the processor and is configured to generate an output based on relaxation of the sample as a function of the perturbation.Type: ApplicationFiled: April 9, 2012Publication date: November 15, 2012Applicant: Regents of the University of MinnesotaInventors: Shalom Michaeli, Silvia Mangia, Dennis J. Sorce, Michael G. Garwood, Timo Liimatainen
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Patent number: 7932719Abstract: A system includes a signal generator and a processor. The signal generator is configured to couple with a magnetic resonance transmitter coil. The processor is configured to execute instructions to control the signal generator. The instructions include forming a sequence of waveforms. The sequence is configured to generate spin relaxation in a fictitious field in a third rotating frame of reference based on at least one magnetic field component that arises based on an effective field in a second rotating frame of reference. The third rotating frame of reference is of a higher order than the second rotating frame of reference and the second rotating frame of reference is of a higher order than the first rotating frame of reference.Type: GrantFiled: March 25, 2010Date of Patent: April 26, 2011Assignee: Regents of the University of MinnesotaInventors: Timo Liimatainen, Michael G. Garwood, Dennis J. Sorce, Shalom Michaeli
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Publication number: 20100237866Abstract: A system includes a signal generator and a processor. The signal generator is configured to couple with a magnetic resonance transmitter coil. The processor is configured to execute instructions to control the signal generator. The instructions include forming a sequence of waveforms. The sequence is configured to generate spin relaxation in a fictitious field in a third rotating frame of reference based on at least one magnetic field component that arises based on an effective field in a second rotating frame of reference. The third rotating frame of reference is of a higher order than the second rotating frame of reference and the second rotating frame of reference is of a higher order than the first rotating frame of reference.Type: ApplicationFiled: March 25, 2010Publication date: September 23, 2010Applicant: Regents of the University of MinnesotaInventors: Timo Liimatainen, Michael G. Garwood, Dennis J. Sorce, Shalom Michaeli
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Patent number: 7279899Abstract: This document discusses, among other things, a system and method for modulating transverse and longitudinal relaxation time contrast in a rotating frame based on a train of radio frequency pulses.Type: GrantFiled: October 6, 2005Date of Patent: October 9, 2007Assignee: Regents of the University of MinnesotaInventors: Shalom Michaeli, Michael G. Garwood, Kamil Ugurbil, Dennis J. Sorce
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Publication number: 20060244447Abstract: This document discusses, among other things, a system and method for modulating transverse and longitudinal relaxation time contrast in a rotating frame based on a train of radio frequency pulses.Type: ApplicationFiled: October 6, 2005Publication date: November 2, 2006Inventors: Shalom Michaeli, Michael Garwood, Kamil Ugurbil, Dennis Sorce