Abstract: The invention provides a controlled release dissolution and diffusion devices which can deliver an active ingredient at a constant or controlled-variable rate comprising an active ingredient and dissolution modifiers and/or an insoluble matrix. The compressed core is coated, except for at least one exposed face, with a coating containing an insoluble polymer or a mixture of an insoluble polymer and pore-forming elements said pore-forming elements having a dissolution rate slower that the release rate so that the pore formation is completed after release of the active ingredients and the residual inert structures disintegrate.

Abstract: A chronotherapy tablet is provided for oral administration and the amelioration of at least one chronobiological condition within 24 hours comprising a substantially oblong core having a longitudinal axis, a first end and a second end, the core being comprised of at least two superposed layers of different compositions wherein an interface between each layer is substantially perpendicular to the longitudinal axis of the core and wherein at least one of the layers is a pharmacological composition; a coating which envelops the core, except for at least one exposed release face of the core at at least one end of the core. Methods are provided for the prevention and/or treatment of asthma, arthritis (including, but not limited to, osteoarthritis and rheumatoid arthritis), gastrointestinal disorders, cardiovascular disease (including, but not limited to, hypertension, angina, myocardial infarction, and stroke), and cancer.

Abstract: The invention provides a controlled release dissolution and diffusion devices which can deliver an active ingredient at a constant or controlled-variable rate comprising an active ingredient and dissolution modifiers and/or an insoluble matrix. The compressed core is coated, except for at least one exposed face, with a coating containing an insoluble polymer or a mixture of an insoluble polymer and pore-forming elements said pore-forming elements having a dissolution rate slower that the release rate so that the pore formation is completed after release of the active ingredients and the residual inert structures disintegrate.

Abstract: The invention provides a controlled release dissolution and diffusion devices which can deliver an active ingredient at a constant or controlled-variable rate comprising an active ingredient and dissolution modifiers and/or an insoluble matrix. The compressed core is coated, except for at least one exposed face, with a coating containing an insoluble polymer or a mixture of an insoluble polymer and pore-forming elements said pore-forming elements having a dissolution rate slower that the release rate so that the pore formation is completed after release of the active ingredients and the residual inert structures disintegrate.