Patents by Inventor Sham-Yuen Chan

Sham-Yuen Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhanced production of morinda metabolites
    Patent number: 9968645
    Abstract: This invention concerns a genetic transformation method to induce hairy root culture of Morinda species, such as Morinda officinalis How, to increase production of therapeutically useful metabolites, related extracts of the roots, and methods to treat ulcerative colitis using extracts of Morinda species, such as Morinda officinalis How.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: May 15, 2018
    Inventor: Sham Yuen Chan
  • FACTOR VIII GLYCOFORMS
    Publication number: 20170267745
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Application
    Filed: April 5, 2017
    Publication date: September 21, 2017
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Myung-Sam CHO, Sham-Yuen CHAN
  • Method for treating bleeding disorders
    Patent number: 9650431
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: May 16, 2017
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • METHOD FOR ENHANCED PRODUCTION OF MORINDA METABOLITES
    Publication number: 20160220625
    Abstract: This invention concerns a genetic transformation method to induce hairy root culture of Morinda species, such as Morinda officinalis How, to increase production of therapeutically useful metabolites, related extracts of the roots, and methods to treat ulcerative colitis using extracts of Morinda species, such as Morinda officinalis How.
    Type: Application
    Filed: December 30, 2015
    Publication date: August 4, 2016
    Inventor: Sham Yuen Chan
  • FACTOR VIII GLYCOFORMS
    Publication number: 20160115219
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Application
    Filed: December 30, 2015
    Publication date: April 28, 2016
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 9284591
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: March 15, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Compositions containing factor VIII glycoforms
    Patent number: 9249209
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: February 2, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • Use of Molecular Chaperones for the Enhanced Production of Secreted, Recombinant Proteins in Mammalian Cells
    Publication number: 20150037841
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Application
    Filed: June 6, 2014
    Publication date: February 5, 2015
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Factor VIII glycoforms
    Patent number: 8945869
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: February 3, 2015
    Assignee: Bayer Healthcare LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 8772027
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 8, 2014
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 8765466
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 1, 2014
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Use of Molecular Chaperones for the Enhanced Production of Secreted, Recombinant Proteins in Mammalian Cells
    Publication number: 20130330820
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 12, 2013
    Applicant: BAYER PHARMACEUTICALS CORPORATION
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Use of Molecular Chaperones for the Enhanced Production of Secreted, Recombinant Proteins in Mammalian Cells
    Publication number: 20130330819
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 12, 2013
    Applicant: BAYER PHARMACEUTICALS CORPORATION
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • FACTOR VIII GLYCOFORMS
    Publication number: 20130267468
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 10, 2013
    Inventors: Myung-Sam CHO, Sham-Yuen Chan
  • Factor VIII Glycoforms
    Publication number: 20130143818
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Application
    Filed: May 29, 2012
    Publication date: June 6, 2013
    Applicant: Bayer HealthCare LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 8409857
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: April 2, 2013
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Methods of reducing hemorrhage due to surgical procedure
    Patent number: 8207117
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: June 26, 2012
    Assignee: Bayer Healthcare LLC
    Inventors: Myung-Sam Cho, Sham-Yuen Chan
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 8192985
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: June 5, 2012
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Use of Molecular Chaperones for the Enhanced Production of Secreted, Recombinant Proteins in Mammalian Cells
    Publication number: 20120009670
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Application
    Filed: May 25, 2011
    Publication date: January 12, 2012
    Applicant: BAYER PHARMACEUTICALS CORPORATION
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Methods of Reducing Hemorrhage Due to Surgical Procedure
    Publication number: 20110144025
    Abstract: The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
    Type: Application
    Filed: November 8, 2010
    Publication date: June 16, 2011
    Applicant: BAYER HEALTHCARE LLC
    Inventors: MYUNG-SAM CHO, SHAM-YUEN CHAN