Patents by Inventor Shamal Mehta

Shamal Mehta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 3-carboxamido isoxazoles as kinase modulators
    Patent number: 7767670
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: August 3, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Shamal A. Mehta, Robert M. Grotzfeld, Zdravko V. Milanov, Andiliy G. Lai, Hitesh K. Patel, David J. Lockhart
  • UREA DERIVATIVES AS ABL MODULATORS
    Publication number: 20100173917
    Abstract: The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: February 26, 2010
    Publication date: July 8, 2010
    Inventors: Robert M. Grotzfeld, Hitesh K. Patel, Shamal A. Mehta, Zdravkö V. Milanov, Andiliy G. Lai
  • Isoxazolyl urea derivatives as kinase modulators
    Patent number: 7750160
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: July 6, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Zdravko V. Milanov, Hitesh K. Patel, Robert M. Grotzfeld, Shamal A. Mehta, Andiliy G. Lai, David J. Lockhart
  • CONJUGATED SMALL MOLECULES
    Publication number: 20100048890
    Abstract: Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.
    Type: Application
    Filed: June 30, 2009
    Publication date: February 25, 2010
    Inventors: Robert M. Grotzfeld, Zdravko V. Milanov, Hitesh K. Patel, Andiliy G. Lai, Shamal A. Mehta, David J. Lockhart
  • Urea derivatives as FLT-3 modulators
    Publication number: 20050267182
    Abstract: The invention provides methods and compositions for treating conditions mediated FLT-3. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: December 1, 2005
    Inventors: Zdravko Milanov, Shamal Mehta, Robert Grotzfeld, Andiliy Lai, Hitesh Patel, David Lockhart
  • Amide derivatives as kinase modulators
    Publication number: 20050261315
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: November 24, 2005
    Inventors: Shamal Mehta, Robert Grotzfeld, Zdravko Milanov, Andiliy Lai, Hitesh Patel, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050239806
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: October 27, 2005
    Inventors: Shamal Mehta, Andiliy Sai, Zdravko Milanov, Robert Grotzfeld, Hitesh Patel, David Lockhart
  • Urea derivatives as PDGFR modulators
    Publication number: 20050197371
    Abstract: The invention provides methods and compositions for treating conditions mediated by PDGFR. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 8, 2005
    Inventors: Zdravko Milanov, Hitesh Patel, Robert Grotzfeld, Shamal Mehta, Andiliy Lai, David Lockhart
  • Urea derivatives as C-kit modulators
    Publication number: 20050192314
    Abstract: The invention provides methods and compositions for treating conditions mediated by c-kit kinase. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 1, 2005
    Inventors: Shamal Mehta, Zdravko Milanov, Robert Grotzfeld, Hitesh Patel, Andiliy Lai, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050187389
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: August 25, 2005
    Inventors: Zdravko Milanov, Shamal Mehta, Andiliy Lai, Hitesh Patel, Robert Grotzfeld, David Lockhart
  • Pyrrole compounds and uses thereof
    Publication number: 20050182125
    Abstract: The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, neuroinflammatory disorders, vascular disorders with an inflammatory component, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 18, 2005
    Applicant: Ambit Biosciences Corporation
    Inventors: David Lockhart, Hitesh Patel, Zdravko Milanov, Shamal Mehta, Patrick Zarrinkar, William Biggs, Pietro Ciceri, Miles Fabian, Daniel Treiber
  • Amide derivatives as PDGFR modulators
    Publication number: 20050171172
    Abstract: The invention provides methods and compositions for treating conditions mediated by PDGFR wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 4, 2005
    Inventors: Andiliy Lai, Shamal Mehta, Zdravko Milanov, Robert Grotzfeld, Hitesh Patel, David Lockhart
  • Amide derivatives as FLT-3 modulators
    Publication number: 20050171171
    Abstract: The invention provides methods and compositions for treating conditions mediated by flt-3 wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 4, 2005
    Inventors: Shamal Mehta, Robert Grotzfeld, Zdravko Milanov, Andiliy Lai, Hitesh Patel, David Lockhart
  • Urea derivatives as kinase modulators
    Publication number: 20050165024
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Zdravko Milanov, Hitesh Patel, Robert Grotzfeld, Shamal Mehta, Andiliy Lai, David Lockhart
  • Amide derivatives as C-KIT modulators
    Publication number: 20050165074
    Abstract: The invention provides methods and compositions for treating conditions mediated by c-kit wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Robert Grotzfeld, Zdravko Milanov, Shamal Mehta, Andiliy Lai, Hitesh Patel, David Lockhart
  • Urea derivatives as ABL modulators
    Publication number: 20050165031
    Abstract: The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Robert Grotzfeld, Hitest Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050165029
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 28, 2005
    Inventors: Hitesh Patel, Shamal Mehta, Andiliy Lai, Zdravko Milanov, Robert Grotzfeld, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050153989
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 14, 2005
    Inventors: Robert Grotzfeld, Hitesh Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart
  • Conjugated small molecules
    Publication number: 20050153371
    Abstract: Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.
    Type: Application
    Filed: January 7, 2005
    Publication date: July 14, 2005
    Inventors: Robert Grotzfeld, Zdravko Milanov, Hitesh Patel, Andiliy Lai, Shamal Mehta, David Lockhart
  • Amide derivatives as ABL modulators
    Publication number: 20050148605
    Abstract: The invention provides methods and compositions for treating conditions mediated by abl wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 7, 2005
    Inventors: Robert Grotzfeld, Hitesh Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart