Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.

Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.

Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.

Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.

Abstract: Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.

Abstract: A method and system for enabling a client to programmatically manage the lifetime of groups of distributed resources is herein provided. The method includes grouping client-specific resource data usage generated from blocks of instruction sequences bounded by scope instructions. A “begin scope” instruction invokes a method initiating the temporal scope. Client-specific resource data generated during execution of subsequent instructions is tracked by the distributed infrastructure. When an “end scope” instruction is received, the client-specific resource data tracked under the temporal scope is deleted from the distributed infrastructure. Client-specific resource data may be tracked under two types of temporal scopes: a transient and a persistent temporal scope. Data tracked under a transient scope does not survive beyond the lifetime of the client connection, whereas data tracked under a persistent scope may survive beyond the lifetime of the client connection. Lastly, temporal scopes may generally be nested.

Abstract: A multi-layer integrated semiconductor structure including a first device layer having a first plurality of semiconductor elements. A first insulating layer is disposed over the first device layer and includes at least a first via-hole. A first conductive plug is disposed in the first via-hole. An interface portion is disposed over at least the first conductive plug. The multi-layer integrated semiconductor structure further includes a second device layer. The second device layer includes a second plurality of semiconductor elements disposed on a top surface of a substrate, which includes a second via-hole. A second conductive plug is disposed in the second via-hole. The second device layer is aligned and coupled to the first device layer via the interface portion so that the interface portion provides a communication relationship between the first device layer and the second device layer.