Patents by Inventor Shamsun Nahar Khan

Shamsun Nahar Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing tibolone metabolites by fermentation with
    Patent number: 8198041
    Abstract: A method of producing ?1,4-Tibolone (C21H26O2), 10?-Hydroxy-?4-tibolone (C21H28O3). 11?,15?-Dihydroxytibolone (C21H28O4) and 11?,15?-Dihydroxy-?5-tibolone (C21H28O4) by contacting tibolone and 3?,6?-Dihydroxytibolone (C21H32O3) by contacting 3?-hydroxytibolone with Cunninghamella elegans (ATCC 10028b) is reported.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: June 12, 2012
    Inventors: Attaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with
    Patent number: 8148558
    Abstract: Method of producing ?4-Tibolone by contacting tibolone with Fusarium lini (ATCC 9593) is reported.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: April 3, 2012
    Inventors: Attaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with
    Patent number: 8148557
    Abstract: Method of producing ?5-Tibolone (C21H28O2), 6?-Hydroxy-?4-tibolone (C21H28O3), 6?-Hydroxy-?4-tibolone (C21H28O3), 15?-Hydroxy-?4-tibolone (C21H28O3), 6?-Hydroxy-?1,4-tibolone (C21H28O3) and 6?-Methoxy-?4-tibolone (C22H30O3) contacting tibolone with Gibberella fujikuroi (ATCC 10704) is reported.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: April 3, 2012
    Inventors: Attaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with
    Patent number: 8148556
    Abstract: A new method of producing metabolites of tibolone comprising fermenting tibolone with Rhizopus stolonifer (ATCC 12938) resulting in the formation of ?4-Tibolone (C21H28O2), 6?-Hydroxytibolone, and 15?-Hydroxytibolone (C21H28O3) is reported.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: April 3, 2012
    Inventors: Attaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with Fusarium lini
    Publication number: 20110124042
    Abstract: Method of producing ?4-Tibolone by contacting tibolone with Fusarium lini (ATCC 9593) is reported.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: INTERNATIONAL CENTER FOR CHEMICAL SCIENCES
    Inventors: Attaur Rahman, Mohammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with Cunninghamella elegans
    Publication number: 20110124044
    Abstract: A method of producing ?1,4-Tibolone (C21H26O2), 10?-Hydroxy-?4-tibolone (C21H28O3). 11?,15?-Dihydroxytibolone (C21H28O4) and 11?,15?-Dihydroxy-?5-tibolone (C21H28O4) by contacting tibolone and 3?,6?-Dihydroxytibolone (C21H32O3) by contacting 3?-hydroxytibolone with Cunninghamella elegans (ATCC 10028b) is reported.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: INTERNATIONAL CENTER FOR CHEMICAL SCIENCES
    Inventors: Attaur Rahman, Mohammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi
    Publication number: 20110124043
    Abstract: Method of producing ?5-Tibolone (C21H28O2), 6?-Hydroxy-?4-tibolone (C21H28O3), 6?-Hydroxy-?4-tibolone (C21H28O3), 15?-Hydroxy-?4-tibolone (C21H28O3), 6?-Hydroxy-?1,4-tibolone (C21H28O3) and 6?-Methoxy-?4-tibolone (C22H30O3) contacting tibolone with Gibberella fujikuroi (ATCC 10704) is reported.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: INTERNATIONAL CENTER FOR CHEMICAL SCIENCES
    Inventors: Attaur Rahman, Mohammad Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer
    Publication number: 20110124041
    Abstract: A new method of producing metabolites of tibolone comprising fermenting tibolone with Rhizopus stolonifer (ATCC 12938) resulting in the formation of ?4-Tibolone (C21H28O2), 6?-Hydroxytibolone, and 15?-Hydroxytibolone (C21H28O3) is reported.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: INTERNATIONAL CENTER FOR CHEMICAL SCIENCES
    Inventors: Attaur Rahman, Mohammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • ?-glucosidase inhibitors from lichens
    Patent number: 7867989
    Abstract: This invention is directed to a novel method for the inhibition of ?-glucosidase enzyme and thus treating diabetes, viral infections, fungal infections, autoimmune function disorders and obesity using compounds derived as lichen metabolites; more specifically, this includes the therapeutic applications of methylorsellinate (2,4-dihydroxy-6-methylbenzoate, Compound I), methyl-?-orinolcarboxylate (2,4-dihydroxy-3,6-dimethylbenzoate, Compound II) and zeorin (6,22-hopanediol, Compound III).
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: January 11, 2011
    Inventors: Vinitha Moolchand Thadani, Shamsun Nahar Khan, Veranja Karunratne, Muhammad Iqbal Choudhary
  • Alpha-glucosidase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones
    Publication number: 20090137542
    Abstract: Sixteen new and one known metabolites were obtained by incubation of tibolone and hydroxytibolones with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. These metabolites have shown promising inhibitory activities against ?-glucosidase enzyme. Seven metabolites exhibited potent inhibitory activity against the ?-glucosidase enzyme and were thus found useful in the treatment of diabetes mellitus and other diseases related to the activity of ?-glucosidase enzyme.
    Type: Application
    Filed: November 23, 2007
    Publication date: May 28, 2009
    Applicant: International Center for Chemical Sciences
    Inventors: Attaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
  • New alpha-glucosidase inhibitors and antibacterial compounds from Myrtus communis L.
    Publication number: 20080269510
    Abstract: Three new acylphloroglucinols, myrtucommulone-D (Compound 1), myrtucommulone-E (Compound 2), myrtucommulone-C (Compound 3), and a known acyphloroglucinol myrtucommulone B (Compound 4) were isolated from a methanolic extract of Myrtus communis L. The structures of compounds 1, 2 and 4 were also unambiguously determined by single X-ray diffraction analysis. The compounds 1-4 were found to be more potent ?-glucosidase inhibitors than the clinically used standards, acarbose and deoxynojirimycin. The compound 3 exhibited the highest activity among all the acylphloroglucinols, with an IC50=35.4±1.15 ?M. The compounds 1 and 2 also exhibited strong antibacterial activities.
    Type: Application
    Filed: December 23, 2005
    Publication date: October 30, 2008
    Applicant: INTERNATIONAL INSTITUTE OF CHEMICAL SCIENCES
    Inventors: Attaur Rahman, Mohammad Iqbal Choudhary, Farzana Shaheen, Manzoor Ahmad, Shamsun Nahar Khan, Shazia Anjum
  • Novel alpha-Glucosidase inhibitor from Tabernaemontana dichotoma
    Publication number: 20080103201
    Abstract: This invention is directed to a novel pharmacological property of ?-Amyrin acetate derived from Tabernaemontana dichotoma as a potent ?-glycosidase inhibitor, which has not been reported before. The present discovery also provides for the use of this compound as a new oral hypoglycemic drug in the treatment of type II diabetes being approximately 35 times potent compared with Acarbose, a standard drug widely prescribed to type II diabetes patients.
    Type: Application
    Filed: October 26, 2006
    Publication date: May 1, 2008
    Inventors: Mirihanage Don Jayantha Wijayabandara, Shamsun Nahar Khan, Muhammad Iqbal Choudhary