Patents by Inventor Shan-Ming Kuang

Shan-Ming Kuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of a pharmaceutically active substance
    Patent number: 8865735
    Abstract: The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: October 21, 2014
    Assignees: Hoffman-La Roche Inc., Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Gary Conard Visor, Shan-Ming Kuang, Baoshu Zhao, Ralph Diodone, Karsten Fähnrich, Urs Schwitter
  • Solid forms of a pharmaceutically active substance
    Patent number: 8748455
    Abstract: The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: June 10, 2014
    Assignees: Plexxikon Inc., Hoffman-La Roche Inc.
    Inventors: Prabha N. Ibrahim, Gary Conard Visor, Shan-Ming Kuang, Baoshu Zhao, Ralph Diodone, Karsten Fähnrich, Urs Schwitter
  • SOLID FORMS OF A PHARMACEUTICALLY ACTIVE SUBSTANCE
    Publication number: 20140039002
    Abstract: The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
    Type: Application
    Filed: February 21, 2012
    Publication date: February 6, 2014
    Applicants: F. Hoffmann-La Roche AG, Plexxikon Inc.
    Inventors: Ralph Diodone, Karsten Fähnrich, Urs Schwitter, Shan-Ming Kuang, Baoshu Zhao, Prabha N. Ibrahim, Gary Conard Visor
  • Solid forms of 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine
    Patent number: 8329912
    Abstract: The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: December 11, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas Cleary, Alexander Glomme, Olaf Grassmann, Shan-Ming Kuang, Roland Meier, Doreen Miller, Regina Moog, Franziska E. Rohrer, Jason Yang
  • Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine
    Publication number: 20120035222
    Abstract: The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Inventors: Thomas Cleary, Alexander Glomme, Olaf Grassmann, Shan-Ming Kuang, Roland Meier, Doreen Miller, Regina Moog, Franziska E. Rohrer, Jason Yang
  • Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine
    Patent number: 8063076
    Abstract: The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: November 22, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas Cleary, Alexander Glomme, Olaf Grassmann, Shan-Ming Kuang, Roland Meier, Doreen Miller, Regina Moog, Franziska E. Rohrer, Jason Yang
  • METHODS FOR THE PREPARATION OF INDAZOLE-3-CARBOXYLIC ACID AND N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE SALT
    Publication number: 20110172428
    Abstract: The present invention provides novel methods for preparing indazole-3-carboxylic acid 2, a key starting material for the manufacture of agonists or partial agonists of the nicotinic ?-7 receptor, such as N—(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 13. Nicotinic ?-7 receptor agonists and partial agonists are being useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing indazole-3-carboxylic acid on scaled-up levels.
    Type: Application
    Filed: January 4, 2011
    Publication date: July 14, 2011
    Inventors: Shan-Ming Kuang, Pingsheng Zhang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7968718
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • FORMULATIONS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE
    Publication number: 20100292246
    Abstract: The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
    Type: Application
    Filed: July 30, 2010
    Publication date: November 18, 2010
    Inventors: Chong-Hui Gu, Qi Gao, Shan-Ming Kuang, Chiajen Lai, Jaquan Kalani Levons, Feng Qian
  • Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-C]pyridine-3-yl]-ethane-1,2-dione
    Patent number: 7829711
    Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: November 9, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. Matiskella, Chenkou Wei, Qi Gao, Chong-Hui Gu, Shan-Ming Kuang
  • PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN
    Publication number: 20100076191
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 25, 2010
    Inventors: NACHIMUTHU SOUNDARARAJAN, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7601715
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • CRYSTALLINE MATERIALS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE
    Publication number: 20090227794
    Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
    Type: Application
    Filed: May 19, 2009
    Publication date: September 10, 2009
    Inventors: John D. Matiskella, Chenkou Wei, Qi Gao, Chong-Hui Gu, Shan-Ming Kuang
  • SOLID FORMS OF 2-CHLORO-4-[1-(4-FLUORO-PHENYL)-2,5-DIMETHYL-1H-IMIDAZOL-4-YLETHYNYL]-PYRIDINE
    Publication number: 20080312288
    Abstract: The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine.
    Type: Application
    Filed: December 17, 2007
    Publication date: December 18, 2008
    Inventors: Thomas Cleary, Alexander Glomme, Olaf Grassmann, Shan-Ming Kuang, Roland Meier, Doreen Miller, Regina Moog, Franziska E. Rohrer, Jason Yang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Publication number: 20060293304
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 28, 2006
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth Natalie, Shawn Pack, Nathan Reising, Erqing Tang, Michael Fakes, Qi Gao, Feng Qian, Blisse Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
    Publication number: 20060100209
    Abstract: The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 11, 2006
    Inventors: Chong-Hui Gu, Qi Gao, Shan-Ming Kuang, Chiajen Lai, Jaquan Levons, Feng Qian
  • Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
    Publication number: 20060100432
    Abstract: The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 11, 2006
    Inventors: John Matiskella, Chenkou Wei, Qi Gao, Chong-Hui Gu, Shan-Ming Kuang