Abstract: A biosensor comprising an electrode and inverted molecular pendulums (iMPs) is described. Each IMP includes a linker bound to the electrode, and an analyte receptor and a redox reporter both bound to the linker. The redox reporter is reactive at positive potential when the linker presents a net negative charge and reactive at negative potential when the linker presents a net positive charge. Upon application of an electric field, the biosensor is characterized by an iMPs unbound state, where no analyte is bound to the receptor, at which the iMPs are displaced towards the electrode and electron transfer from the iMPs towards the electrode occurs at an unbound electron transfer rate, and an iMPs bound state, where the analyte is bound to the receptor, at which the iMPs are displaced towards the electrode and electron transfer from the iMPs towards the electrode occurs at a bound electron transfer rate.

Abstract: There is described herein compound comprising a mitochondrial targeting portion, a cargo portion including a drug unit, and a linker conjugating the mitochondrial targeting portion and the cargo portion, the linker portion cleavable in a mitochondrion of a cell for preferentially releasing the cargo portion within the mitochondrion as compared to a cytoplasm of the cell.

Abstract: Methods and devices for magnetic profiling of target particles in a flow. There are a plurality of flow rate-reducing structures in a flow chamber. Each flow rate-reducing structure is provided with a localized magnetic attractive force, the magnetic attractive force defining a capture zone in the vicinity of the flow rate-reducing structure. The size of capture zones may be variable for different locations within the device. The magnetic attractive force, in the capture zone, is sufficiently high to overcome the drag force on a given subset of the target particles to promote capture of any particles belonging to the subset of the target particles in the capture zone. Different target particles having different magnetic susceptibility are captured in different capture zones.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: There is described herein a method for the electrochemical quantification of a protein analyte in sample, comprising: providing one or more electrode(s), each comprising at least one peptide attached to its surface, the peptide being the protein or a fragment thereof; contacting the sample and electrode with an antibody in the presence of a redox reporter, wherein the antibody is capable of binding to each of the protein analyte and the peptide on the electrode; measuring an electrochemical signal generated by the redox reporter when a potential is applied; quantifying the protein analyte by comparing the electrochemical signal generated with a control, wherein the electrochemical signal is indirectly proportional to the amount of protein analyte in the sample.

Abstract: Methods and devices for magnetic profiling of target particles in a flow. There are a plurality of flow rate-reducing structures in a flow chamber. Each flow rate-reducing structure is provided with a localized magnetic attractive force, the magnetic attractive force defining a capture zone in the vicinity of the flow rate-reducing structure. The size of capture zones may be variable for different locations within the device. The magnetic attractive force, in the capture zone, is sufficiently high to overcome the drag force on a given subset of the target particles to promote capture of any particles belonging to the subset of the target particles in the capture zone. Different target particles having different magnetic susceptibility are captured in different capture zones.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anticancer compound, and their method of use.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anti-cancer compound, and their method of use.

Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.

Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

Abstract: The detection of specific nucleic acid sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor nucleic acid hybridization. Furthermore, the new assay when used on nanoscale electrodes, provides ultrasensitive detection of nucleic acids.

Abstract: The detection of specific DNA sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor DNA hybridization.

Abstract: The detection of specific nucleic acid sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor nucleic acid hybridization. Furthermore, the new assay when used on nanoscale electrodes, provides ultrasensitive detection of nucleic acids.