Abstract: An optical device includes a low-noise illumination source, a support device, an ultra low-noise detector, an analog-to-digital converter, and a controller. The low-noise illumination source is configured to generate a single beam of radiation. The support device is configured to support an object and to pass the single beam of radiation through the object. The object directly blocks, absorbs, or deflects portions of the single beam of radiation, thereby directly modulating the single beam of radiation. The low-noise detector is configured to detect the modulated single beam of radiation and to output an analog signal representative of vibrational spectra of the object. The modulated single beam of radiation is non-interferometric. The analog-to-digital converter is configured to convert the detected analog signal into a digital signal. The controller is configured to analyze and generate vibrational spectra of the object from the digital signal represented as a range of events over time.

Abstract: Disclosed are systems and methods for measuring vibrational spectra of a living cells and tissue that includes a low noise consistent optical source creating a photon beam, a support device, a photon-to-electron converter/detector outputting a streamed analog electrical signal, an analog-to-digital converter, and a digital signal processor with specialized software for measuring and characterizing the signal contained in the photon beam and its subsequent detector's streamed analog converted to digital signal. Motion of the living sample causes modulation to the photon beam as it passes through the living samples by how much of the photon beam is blocked, absorbed or deflected. In addition, specific sub-cellular vibrational features can be segregated utilizing fluorescent markers.

Abstract: Disclosed are systems and methods for measuring vibrational spectra of a living cells and tissue that includes a low noise consistent optical source creating a photon beam, a support device, a photon-to-electron converter/detector outputting a streamed analog electrical signal, an analog-to-digital converter, and a digital signal processor with specialized software for measuring and characterizing the signal contained in the photon beam and its subsequent detector's streamed analog converted to digital signal. Motion of the living sample causes modulation to the photon beam as it passes through the living samples by how much of the photon beam is blocked, absorbed or deflected. In addition, specific sub-cellular vibrational features can be segregated utilizing fluorescent markers.

Abstract: A machine-implemented method for computerized digital signal processing obtains a digital signal from data storage or from conversion of an analog signal and determines, from the digital signal, Measuring Matrices (MM). Each measuring matrix has a plurality of cells, each cell having an amplitude corresponding to the signal energy in a frequency bin for a time slice. Cells in each measuring matrix having maximum amplitudes within a time slice are identified as maximum cells. Maxima that coincide in time and frequency are identified and a correlated maxima matrix (PMM) is constructed showing the coinciding maxima and the adjacent marked maxima are linked into partial chains. If only one MM is constructed, multiple types of maxima are identified to generate the (PMM). The partial chains are isolated by parameters for a single domain or multiple domains to identify partial chains and possible separation of complex compound waveforms in the digital signal.

Abstract: A machine/computer implemented system, method, and computer program product for scored pixel intensity value adjustment of a digital image is disclosed. The system is configured to obtain a digital image from data storage and perform pixel-by-pixel comparisons to generate per pixel scores. The types of comparisons include discovering minima and maxima per pixel scores by comparing to neighboring non-adjacent pixel pairs, delta pair scores by comparing to neighboring pixels, and multiple vector score types by comparing to vectors made up of individual pixels. This new information is applied to adjust each pixel's value. The system is further configured to generate a collection of such scores for a plurality of pixels in a digital image and to generate a multi-dimensional scored pixel adjusted image. The scored pixel adjustment yields a new digital image, wherein the value of a given pixel is adjusted based on one or more of the score types.

Abstract: A machine/computer implemented system, method, and computer program product for scored pixel intensity value adjustment of a digital image is disclosed. The system is configured to obtain a digital image from data storage and perform pixel-by-pixel comparisons to generate per pixel scores. The types of comparisons include discovering minima and maxima per pixel scores by comparing to neighboring non-adjacent pixel pairs, delta pair scores by comparing to neighboring pixels, and multiple vector score types by comparing to vectors made up of individual pixels. This new information is applied to adjust each pixel's value. The system is further configured to generate a collection of such scores for a plurality of pixels in a digital image and to generate a multi-dimensional scored pixel adjusted image. The scored pixel adjustment yields a new digital image, wherein the value of a given pixel is adjusted based on one or more of the score types.

Abstract: A machine/computer implemented system, method, and computer program product for scored pixel intensity value adjustment of a digital image is disclosed. The system is configured to obtain a digital image from data storage and perform pixel-by-pixel comparisons to generate per pixel scores. The types of comparisons include discovering minima and maxima per pixel scores by comparing to neighboring non-adjacent pixel pairs, delta pair scores by comparing to neighboring pixels, and multiple vector score types by comparing to vectors made up of individual pixels. This new information is applied to adjust each pixel's value. The system is further configured to generate a collection of such scores for a plurality of pixels in a digital image and to generate a multi-dimensional scored pixel adjusted image. The scored pixel adjustment yields a new digital image, wherein the value of a given pixel is adjusted based on one or more of the score types.