Patents by Inventor Shane Lauson Hubler

Shane Lauson Hubler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for processing tandem mass spectral data for protein sequence analysis
    Patent number: 8278115
    Abstract: Various mass spectroscopy-based methods are provided to improve protein sequencing by detecting z-type product ions generated from the protein. A polypeptide is introduced to a mass spectrometer, and in particular c- and z-type product ions that are generated by selectively fragmenting the polypeptide. The z-type product ions are distinguished from the c-type product ions and the mass-to-charge ratio of at least a portion of the z-type product ions are determined. From the mass of the z-type product ions, a putative chemical composition is identified for at least a portion of the z-type product ions, c-type product ions, or both, which is used to determine polypeptide compositions. Further provided are various methods for reducing spectral noise, instrument calibration and database searching and verification.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: October 2, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joshua J. Coon, Gheorghe Craciun, Shane Lauson Hubler
  • Methods for Processing Tandem Mass Spectral Data for Protein Sequence Analysis
    Publication number: 20090173878
    Abstract: Various mass spectroscopy-based methods are provided to improve protein sequencing by detecting z-type product ions generated from the protein. A polypeptide is introduced to a mass spectrometer, and in particular c- and z-type product ions that are generated by selectively fragmenting the polypeptide. The z-type product ions are distinguished from the c-type product ions and the mass-to-charge ratio of at least a portion of the z-type product ions are determined. From the mass of the z-type product ions, a putative chemical composition is identified for at least a portion of the z-type product ions, c-type product ions, or both, which is used to determine polypeptide compositions. Further provided are various methods for reducing spectral noise, instrument calibration and database searching and verification.
    Type: Application
    Filed: November 26, 2008
    Publication date: July 9, 2009
    Inventors: Joshua J. COON, Gheorghe CRACIUN, Shane Lauson Hubler