Patents by Inventor Shane Lofgren

Shane Lofgren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHIELDED SMALL NUCLEOTIDES FOR INTRACELLULAR BARCODING
    Publication number: 20250354297
    Abstract: The present disclosure relates to a barcoded RNA comprising a first shield sequence at the 5? end of the barcoded RNA, a barcode sequence, a scaffold sequence, a capture sequence, and a second shield sequence at 3? end of the barcoded RNA. The present disclosure also provides for methods of performing single-cell RNA sequencing using the barcoded RNA. The present disclosure also provides for libraries including the barcoded RNA.
    Type: Application
    Filed: October 31, 2022
    Publication date: November 20, 2025
    Inventors: Xiaoyin LU, Shane LOFGREN, Pawel MAZUR
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20250019688
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g., proteins) in a mixture (e.g., a complex mixture (e.g., in vivo)) using barcodes (e.g., peptide barcodes), binders (e.g., polypeptide binders), and binding agents (e.g., phage) are provided herein.
    Type: Application
    Filed: November 2, 2022
    Publication date: January 16, 2025
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • Methods and compositions for protein detection
    Patent number: 12037706
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: July 16, 2024
    Assignee: Manifold Biotechnologies, Inc.
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • Methods and compositions for protein detection
    Patent number: 11976384
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: May 7, 2024
    Assignee: Manifold Biotechnologies, Inc.
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20240117526
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: August 21, 2023
    Publication date: April 11, 2024
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20230134536
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: November 3, 2021
    Publication date: May 4, 2023
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20230134754
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: April 11, 2022
    Publication date: May 4, 2023
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang