Abstract: IL33 antagonists alone or in combination with IL-4R antagonists can be used to treat or inhibit eosinophilic asthma, eosinophilic COPD, eosinophilic ACOS, and nasal polyps in a subject having one or more risk alleles in the intronic IL1RL1 variant rs1420101, in the IL33 variant rs1342326, in both, or in variants in linkage disequilibrium thereof.

Abstract: IL33 antagonists alone or in combination with IL-4R antagonists can be used to treat or inhibit eosinophilic asthma, eosinophilic COPD, eosinophilic ACOS, and nasal polyps in a subject having one or more risk alleles in the intronic IL1RL1 variant rs1420101, in the IL33 variant rs1342326, in both, or in variants in linkage disequilibrium thereof.

Abstract: Hip arthroplasty apparatus and methods are described to determine an orientation of an acetabular cup impactor, the acetabular cup impactor being moveable to a desired orientation relative to a patient's pelvic region for implantation of an acetabular cup. In one embodiment an electronic orientation sensor is transitionable between a first location on the patient's pelvic region and a second location on the acetabular cup impactor. At the first location, the orientation sensor is adapted to record a reference orientation of the patient's pelvic region. At the second location the orientation sensor is adapted to determine an orientation of the acetabular cup impactor relative to the reference orientation.

Abstract: Hip arthroplasty apparatus and methods are described to determine an orientation of an acetabular cup impactor, the acetabular cup impactor being moveable to a desired orientation relative to a patient's pelvic region for implantation of an acetabular cup. In one embodiment an electronic orientation sensor is transitionable between a first location on the patient's pelvic region and a second location on the acetabular cup impactor. At the first location, the orientation sensor is adapted to record a reference orientation of the patient's pelvic region. At the second location the orientation sensor is adapted to determine an orientation of the acetabular cup impactor relative to the reference orientation.

Abstract: IL33 antagonists alone or in combination with IL-4R antagonists can be used to treat or inhibit eosinophilic asthma, eosinophilic COPD, eosinophilic ACOS, and nasal polyps in a subject having one or more risk alleles in the intronic IL1RL1 variant rs1420101, in the IL33 variant rs1342326, in both, or in variants in linkage disequilibrium thereof.

Abstract: Hip arthroplasty apparatus and methods are described to determine an orientation of an acetabular cup impactor, the acetabular cup impactor being moveable to a desired orientation relative to a patient's pelvic region for implantation of an acetabular cup. In one embodiment an electronic orientation sensor is transitionable between a first location on the patient's pelvic region and a second location on the acetabular cup impactor. At the first location, the orientation sensor is adapted to record a reference orientation of the patient's pelvic region. At the second location the orientation sensor is adapted to determine an orientation of the acetabular cup impactor relative to the reference orientation.

Abstract: Hip arthroplasty apparatus and methods are described to determine an orientation of an acetabular cup impactor, the acetabular cup impactor being moveable to a desired orientation relative to a patient's pelvic region for implantation of an acetabular cup. In one embodiment, an electronic orientation sensor is transitionable between a first location on the patient's pelvic region and a second location on the acetabular cup impactor. In a second embodiment, an image capture device is locatable on the acetabular impactor or the patient's pelvic region to capture images including markers located on the other of the patient's pelvic region or the acetabular impactor.

Abstract: Hip arthroplasty apparatus and methods are described to determine an orientation of an acetabular cup impactor, the acetabular cup impactor being moveable to a desired orientation relative to a patient's pelvic region for implantation of an acetabular cup. In one embodiment, an electronic orientation sensor is transitionable between a first location on the patient's pelvic region and a second location on the acetabular cup impactor. In a second embodiment, an image capture device is locatable on the acetabular impactor or the patient's pelvic region to capture images including markers located on the other of the patient's pelvic region or the acetabular impactor.

Abstract: An orthopaedic device for generating one or more strain signals representative of the strain in a bone in response to a force applied to the bone. The device includes an encircling member (11) for encircling the bone of a subject and a sensor member (13) connected thereto, the sensor member including a strain sensor (14). In a preferred embodiment the strain sensor comprises one or more bridging members configured to break when subjected to a particular strain.

Abstract: The present disclosure relates to compositions and methods for the diagnosis of schizophrenia. In particular, the instant disclosure is directed to identification of novel copy number variants of sequences associated with the VIPR2 gene, including certain micro-duplications and triplications, and correlation of these copy number variants with schizophrenia.

Abstract: An orthopaedic device for generating one or more strain signals representative of the strain in a bone in response to a force applied to the bone. The device includes an encircling member (11) for encircling the bone of a subject and a sensor member (13) connected thereto, the sensor member including a strain sensor (14). In a preferred embodiment the strain sensor comprises one or more bridging members configured to break when subjected to a particular strain.