Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.

Abstract: Disclosed herein are systems and methods for a continuous analyte monitoring system for measuring a concentration of a first analyte and concentration of a second analyte in a host. One such system utilizes a working electrode and a reference electrode to measure glucose concentration and oxygen concentration in bodily fluid of a host. The system includes a sensor control circuit that applies a first bias condition to the sensor to measure a first signal generated by the sensor indicative of a concentration of the first analyte. The sensor control circuit also applies a second bias condition to the sensor to measure a second signal generated by the sensor indicative of a concentration of a second analyte at the host.

Abstract: The present disclosure relates generally to bioactive releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel bioactive releasing membranes, to devices and implantable devices including these membranes, methods for forming the bioactive releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.

Abstract: The present disclosure relates generally to drug releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel drug releasing membranes, to devices and implantable devices including these membranes, methods for forming the drug releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.