Abstract: According to an aspect, a medical device includes an elongate member, a needle, and a suture. The needle is movably coupled to the elongate member. The suture is disposed within a lumen defined by the elongate member. The suture has a coupling member coupled to a first portion of the suture. The coupling member is configured to be coupled to a second portion of the suture.

Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject: a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject, a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: According to an aspect, a device includes an elongate member, a suture, and a needle. The elongate member has a first end portion and a second end portion. The elongate member defines a lumen and a slot. The lumen extends from the first end portion to the second end portion. The slot extends from the first end portion to the second end portion. A portion of the suture is wrapped around the elongate member. The needle is coupled to the suture.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.

Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.

Abstract: A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.

Abstract: According to an aspect, a medical device includes an elongate member, a needle, and a suture. The needle is movably coupled to the elongate member. The suture is disposed within a lumen defined by the elongate member. The suture has a coupling member coupled to a first portion of the suture. The coupling member is configured to be coupled to a second portion of the suture.

Abstract: A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: According to an aspect, a device includes an elongate member, a suture, and a needle. The elongate member has a first end portion and a second end portion. The elongate member defines a lumen and a slot. The lumen extends from the first end portion to the second end portion. The slot extends from the first end portion to the second end portion. A portion of the suture is wrapped around the elongate member. The needle is coupled to the suture.

Abstract: A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.