Patents by Inventor Shang-Hsiu Hu

Shang-Hsiu Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10894020
    Abstract: Provided is a hybrid nanoparticle, including an aggregate assembled from a plurality of polymeric molecules, and a plurality of boron-doped graphene quantum dots localized in the aggregate. The polymeric molecule is preferably a pH-responsive dendrimer; the polymeric molecule and the boron-doped graphene quantum dot may be separately associated with different drugs; and hybrid nanoparticle may further include a targeting molecule, such as a rabies virus glycoprotein. Also provided is a method of controlling disassembly of a hybrid nanoparticle, including applying a high-frequency magnetic field to the hybrid nanoparticle to induce disassembly thereof. Also provided is an application of the hybrid nanoparticle for preparing a tumor-penetrating drug carrier.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: January 19, 2021
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Shang-Hsiu Hu, Yu-Lin Su
  • Publication number: 20200121597
    Abstract: The present disclosure provides an injectable and shearing-thinning microbeads gel including a first microgel and a second microgel. The first microgel has a first electric charge and includes a plurality of first gel microspheres. The second microgel has a second electric charge and includes a plurality of second gel microspheres. The first electric charge is opposite to the second electric charge, the average particle size of the first gel microspheres is equal to the average particle size of the second gel microspheres, each of the first gel microspheres includes an acrylic chitosan polymer, an acrylic silk polymer, or a combination thereof, and each of the second gel microspheres includes an acrylic gelatin polymer, an acrylic hyaluronic acid polymer, an acrylic alginate polymer, or a combination thereof.
    Type: Application
    Filed: August 26, 2019
    Publication date: April 23, 2020
    Inventors: Shang-Hsiu Hu, Ru-Siou Hsu
  • Publication number: 20200060983
    Abstract: Provided is a hybrid nanoparticle, including an aggregate assembled from a plurality of polymeric molecules, and a plurality of boron-doped graphene quantum dots localized in the aggregate. The polymeric molecule is preferably a pH-responsive dendrimer; the polymeric molecule and the boron-doped graphene quantum dot may be separately associated with different drugs; and hybrid nanoparticle may further include a targeting molecule, such as a rabies virus glycoprotein. Also provided is a method of controlling disassembly of a hybrid nanoparticle, including applying a high-frequency magnetic field to the hybrid nanoparticle to induce disassembly thereof. Also provided is an application of the hybrid nanoparticle for preparing a tumor-penetrating drug carrier.
    Type: Application
    Filed: January 4, 2019
    Publication date: February 27, 2020
    Inventors: Shang-Hsiu Hu, Yu-Lin Su
  • Patent number: 9603798
    Abstract: An antibody-conjugated double-emulsion nanocapsule is provided. A linking group is introduced on the surface of a double-emulsion nanocapsule, which is composed of an oily shell enclosing an aqueous core, to link the double-emulsion nanocapsule with an antibody.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: March 28, 2017
    Assignee: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Chih-Sheng Chiang, Shang-Hsiu Hu, San-Yuan Chen
  • Patent number: 9457105
    Abstract: A nano-photoacoustic imaging agent is disclosed. The nano-photoacoustic imaging agent includes a porous carrier and a gold filling material embedded in the porous carrier. A method for the preparation of the nano-photoacoustic imaging agent is also provided.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: October 4, 2016
    Assignee: National Chiao Tung University
    Inventors: San-Yuan Chen, Po-Jung Chen, Dean-Mo Liu, Shang-Hsiu Hu
  • Publication number: 20160199308
    Abstract: The present invention provides a magnetic nano core-shell capsule for drug delivery, which including: a plurality of amphiphilic protein, a plurality of iron oxide nanoparticles, a hydrophilic drug and a hydrophobic drug. Wherein the magnetic nano core-shell capsule has good biocompatibility duo to the amphiphilic protein as the material, and it only needs single step emulsion to form its nano hollow structure. Therefore, the magnetic nano core-shell capsule of the present invention has high drug loading capacity, the ability of encapsulating hydrophobic and hydrophilic pharmaceuticals simultaneously and characteristic of controlled-release drug delivery. Thus it can be used for targeted drug delivery, magnetic resonance imaging and hyperthermia.
    Type: Application
    Filed: March 18, 2015
    Publication date: July 14, 2016
    Inventors: Shang-Hsiu Hu, Yun-Ting Li, Jen-Hung Fang
  • Publication number: 20160089443
    Abstract: A drug carrier includes an aqueous solution, a protein shell, graphenes, and a bioactive agent. The protein shell encloses the aqueous solution, and includes at least one hydrophilic/hydrophobic layer. The graphenes are dispersed in the protein shell, and the bioactive agent is in the aqueous solution and/or the protein shell.
    Type: Application
    Filed: February 4, 2015
    Publication date: March 31, 2016
    Inventors: Shang-Hsiu HU, San-Yuan CHEN, Yen-Ho LAI, Chih-Sheng CHIANG, Min-Yu CHIANG
  • Publication number: 20140356421
    Abstract: An antibody-conjugated double-emulsion nanocapsule is provided. A linking group is introduced on the surface of a double-emulsion nanocapsule, which is composed of an oily shell enclosing an aqueous core, to link the double-emulsion nanocapsule with an antibody.
    Type: Application
    Filed: April 24, 2014
    Publication date: December 4, 2014
    Applicant: National Chiao Tung University
    Inventors: Chih-Sheng Chiang, Shang-Hsiu Hu, San-Yuan Chen
  • Publication number: 20140147388
    Abstract: A nano-photoacoustic imaging agent is disclosed. The nano-photoacoustic imaging agent includes a porous carrier and a gold filling material embedded in the porous carrier. A method for the preparation of the nano-photoacoustic imaging agent is also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 29, 2014
    Applicant: National Chiao Tung University
    Inventors: San-Yuan Chen, Po-Jung Chen, Dean-Mo Liu, Shang-Hsiu Hu
  • Publication number: 20130137917
    Abstract: A double-emulsion core-shell nano-structure and preparation methods thereof is provided. The double-emulsion core-shell nano-structure is a structure of an oil shell enclosing a water core. The double-emulsion core-shell nano-structure can be prepared by simply mixing and stirring to emulsify an aqueous solution of a water soluble polymer and an organic solution of hydrophobic paramagnetic nanoparticles.
    Type: Application
    Filed: February 13, 2012
    Publication date: May 30, 2013
    Applicant: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Bang-Jie Liao, Shang-Hsiu Hu, San-Yuan Chen
  • Publication number: 20130012758
    Abstract: The present invention discloses a magnetically-controllable nanometric porous drug carrier, wherein an organic or inorganic matrix is used to carry the drug, and wherein magnetic nanoparticles having magnetosensitivity are used to encapsulate the surface of the matrix and seal the drug inside the matrix. An external magnetic field is used to control the removal rate of the magnetic nanoparticles and control the behavior and rate of drug release.
    Type: Application
    Filed: November 1, 2011
    Publication date: January 10, 2013
    Inventors: San-Yuan CHEN, Po-Jung CHEN, Dean-Mo LIU, Shang-Hsiu HU
  • Publication number: 20120294806
    Abstract: A drug carrier with thermal sensitivity, a manufacturing method thereof, and a use thereof are disclosed. The drug carrier comprises a nano-magnetic particle, a drug, a composite polymer, and a dense silica shell. The nano-magnetic particle and the drug are encapsulated in the composite polymer which is formed by self-assembly a water-soluble polymer (such as poly vinyl alcohol) and a thermosensitive copolymer (such as Pluronic F68 or Pluronic F127). The stability and drug release of the drug carrier a can be adjusted by combining PVA and thermosensitive copolymer with a different ratio. When an external magnetic field was applied, the cores exhibit significant size shrinkage and the diameter of the drug carrier decreases more than 10 folds due to the change of temperature, which causes burst-like drug release because of shell destruction and physical collapse of the drug carrier.
    Type: Application
    Filed: October 25, 2011
    Publication date: November 22, 2012
    Inventors: San-Yuan CHEN, Shang-Hsiu HU, Hsin-Yang HUANG
  • Publication number: 20110014296
    Abstract: Nanodevice and method for in vivo monitoring and release of drugs are provided. The disclosed nanodevice is characterized in having a drug-loaded nanosphere that is capable of releasing the encapsulated drugs upon magnetically stimulation. The nanodevice may also be used as a contrast agent for in vivo imaging and monitoring the concentration and distribution of the released drugs and/or active compounds injected separately into a target site of a subject.
    Type: Application
    Filed: July 17, 2009
    Publication date: January 20, 2011
    Applicant: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: San-Yuan Chen, Shang-Hsiu Hu, Dean-Mo Liu, Kun-Ting Kuo
  • Publication number: 20090285885
    Abstract: The invention discloses the synthesis and manufacturing of a novel core-shell nano-carrier with a drug-containing nanocomposite core surrounding with a single crystalline magnetic iron oxide shell. With a unique core-shell configuration, active agents such as drugs and biomolecules encapsulated in the core with an outer single-crystalline thin iron oxide shell can be perfectly protected from environmental damages and in the meantime, eliminating un-desirable release due to un-controllable diffusion of the active molecules from the nanocapsules during the course of delivery in patient's body, before reaching the disease sites.
    Type: Application
    Filed: September 9, 2008
    Publication date: November 19, 2009
    Applicant: National Chiao Tung University
    Inventors: San-Yuan Chen, Shang-Hsiu Hu, Dean-Mo Liu