Patents by Inventor Shanghua Xia

Shanghua Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDOPYRROLE SPIRO COMPOUNDS AND DERIVATIVES THEREOF AS DNA-PK INHIBITORS
    Publication number: 20230055321
    Abstract: Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.
    Type: Application
    Filed: November 20, 2020
    Publication date: February 23, 2023
    Inventors: Kevin X CHEN, Shanghua XIA, Zhaoguo CHEN, Zuhao GUO, Yanxin YU, Kai ZHOU, Boyu HU, Li ZHANG, Fen JIANG, Jingjing WANG, Guoping HU, Jian LI, Shuhui CHEN
  • PYRIMIDOIMIDAZOLE COMPOUNDS USED AS DNA-PK INHIBITORS
    Publication number: 20230026616
    Abstract: A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.
    Type: Application
    Filed: November 25, 2020
    Publication date: January 26, 2023
    Inventors: Kevin X CHEN, Shanghua XIA, Zhaoguo CHEN, Zuhao GUO, Yanxin YU, Kai ZHOU, Boyu HU, Li ZHANG, Fen JIANG, Jingjing WANG, Guoping HU, Jian LI, Shuhui CHEN
  • SALT AND CRYSTAL FORM OF MTORC1/2 DUAL KINASE ACTIVITY INHIBITOR AND PREPARATION METHOD THEREFOR
    Publication number: 20220306622
    Abstract: Disclosed are a salt and a crystal form of an mTORC1/2 dual kinase inhibitor and a preparation method therefor. Also disclosed is use of the salt and crystal form in the preparation of a medicament related to the mTORC1/2 dual kinase inhibitor.
    Type: Application
    Filed: May 6, 2020
    Publication date: September 29, 2022
    Inventors: Kevin X CHEN, Zhaoguo CHEN, Li ZHANG, Yanxin YU, Kai ZHOU, Fen JIANG, Shanghua XIA, Xiaofei WANG
  • CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20210292340
    Abstract: Provided by the present application are a cell necrosis inhibitor, a preparation method therefor and a use thereof; in particular, provided by the present application is an inhibitor of cell necrosis and/or human receptor-interacting protein 1 kinase (RIP1). The inhibitor has a structure as shown in the following formula I. The compound and a composition comprising same may be used to prevent and/or treat diseases involving cell death and/or inflammation.
    Type: Application
    Filed: June 25, 2019
    Publication date: September 23, 2021
    Inventors: Dawei MA, Yuhua JI, Weiming HE, Chao FANG, Jinlong ZHAO, Kailiang WANG, Shanghua XIA, Zheng LI, Ying LI
  • EGFR kinase inhibitor and preparation method and use thereof
    Patent number: 10710979
    Abstract: The present invention provides an EGFR kinase inhibitor and a preparation method and use thereof. Specifically, the present invention provides a compound as shown in formula (I), the definition of each group therein being as described in the description. Said compound is an efficient EGFR inhibitor.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: July 14, 2020
    Assignee: ZHEJIANG BOSSAN PHARMACEUTICAL CO. LTD.
    Inventors: Dawei Ma, Qiang Yu, Junying Yuan, Hongguang Xia, Dongpo Cai, Kailiang Wang, Chen Zhang, Shanghua Xia
  • Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides
    Patent number: 10500577
    Abstract: The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: December 10, 2019
    Assignee: CE Pharm CO., LTD
    Inventors: Dawei Ma, Wei Zhou, Mengyang Fan, Haibo Wu, Junli Yin, Shanghua Xia
  • EGFR KINASE INHIBITOR AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20180346444
    Abstract: The present invention provides an EGFR kinase inhibitor and a preparation method and use thereof. Specifically, the present invention provides a compound as shown in formula (I), the definition of each group therein being as described in the description. Said compound is an efficient EGFR inhibitor.
    Type: Application
    Filed: July 11, 2016
    Publication date: December 6, 2018
    Inventors: Dawei MA, Qiang YU, Junying YUAN, Hongguang XIA, Dongpo CAI, Kailiang WANG, Chen ZHANG, Shanghua XIA
  • OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE
    Publication number: 20180207628
    Abstract: The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.
    Type: Application
    Filed: April 15, 2016
    Publication date: July 26, 2018
    Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Inventors: Dawei Ma, Wei Zhou, Mengyang Fan, Haibo Wu, Junli Yin, Shanghua Xia