Patents by Inventor Shanghui Hu

Shanghui Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potent and Efficient Cytotoxic Peptides and Antibody-Drug Conjugates thereof and Their Synthesis
    Publication number: 20160158307
    Abstract: The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
    Type: Application
    Filed: February 15, 2016
    Publication date: June 9, 2016
    Applicant: ACES Pharma Inc.
    Inventors: Shanghui Hu, Lucy Xiumin Zhao, Jinying Ning, Xufang Tian, Chao Li, Wei Hu, Xu Liu, Bonnie Y. Hu
  • Potent and efficient cytotoxic peptides and antibody-drug conjugates thereof and their synthesis
    Patent number: 9260478
    Abstract: The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: February 16, 2016
    Inventors: Shanghui Hu, Lucy Xiumin Zhao, Jinying Ning, Xufang Tian
  • Potent and Efficient Cytotoxic Peptides and Antibody-Drug Conjugates thereof and Their Synthesis
    Publication number: 20150284425
    Abstract: The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
    Type: Application
    Filed: October 16, 2014
    Publication date: October 8, 2015
    Applicant: ACES Pharma Inc.
    Inventors: Shanghui Hu, Lucy Xiumin Zhao, Jinying Ning, Xufang Tian
  • Process for preparing chiral compounds
    Patent number: 9079877
    Abstract: The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 14, 2015
    Assignee: Pfizer Inc.
    Inventors: David W Bauer, Padraig M O'Neill, Timothy J Watson, Shanghui Hu
  • Process for Preparing Chiral Compounds
    Publication number: 20140187794
    Abstract: The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 3, 2014
    Applicant: Pfizer Inc.
    Inventors: David W. Bauer, Padraig M. O'Neill, Timothy J. Watson, Shanghui Hu
  • Process for preparing chiral compounds
    Patent number: 8642783
    Abstract: The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: February 4, 2014
    Assignee: Pfizer Inc.
    Inventors: David W. Bauer, Padraig M. O'Neill, Timothy J. Watson, Shanghui Hu
  • Preparation of pregabalin and related compounds
    Patent number: 8134023
    Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: March 13, 2012
    Assignee: Pfizer Inc
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
  • Preparation of Pregabalin and Related Compounds
    Publication number: 20120015412
    Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Application
    Filed: September 28, 2011
    Publication date: January 19, 2012
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
  • Preparation of pregabalin and related compounds
    Patent number: 8044227
    Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: October 25, 2011
    Assignee: Pfizer Inc.
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
  • Process for Preparing Chiral Compounds
    Publication number: 20110118476
    Abstract: The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
    Type: Application
    Filed: July 23, 2008
    Publication date: May 19, 2011
    Inventors: David W. Bauer, Padraig M. O'Nell, Timothy J. Watson, Shanghui Hu
  • Preparation of Pregabalin and Related Compounds
    Publication number: 20110065168
    Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Application
    Filed: November 22, 2010
    Publication date: March 17, 2011
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
  • Preparation of pregabalin and related compounds
    Patent number: 7838686
    Abstract: Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: November 23, 2010
    Assignee: Pfizer Inc.
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
  • Aminoglycoside-polyamine displacers and methods of use in displacement chromatography
    Patent number: 7439343
    Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: October 21, 2008
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Kaushal Rege, Shanghui Hu, Jonathan S. Dordick, Steven M. Cramer
  • Aminoglycoside-polyamine displacers and methods of use in displacement chromatography
    Publication number: 20070049741
    Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.
    Type: Application
    Filed: September 1, 2005
    Publication date: March 1, 2007
    Inventors: Kaushal Rege, Shanghui Hu, Jonathan Dordick, Steven Cramer
  • Preparation of pregabalin and related compounds
    Publication number: 20050283023
    Abstract: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
    Type: Application
    Filed: June 21, 2005
    Publication date: December 22, 2005
    Inventors: Shanghui Hu, Carlos Martinez, Junhua Tao, William Tully, Patrick Kelleher, Yves Dumond
  • Methods for the preparation of stereoisomerically enriched amines
    Publication number: 20050192441
    Abstract: The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CR7R8)t(C6-C14 aryl), and —(CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, —OR7, and —N(R7R8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
    Type: Application
    Filed: December 3, 2004
    Publication date: September 1, 2005
    Inventors: Shanghui Hu, Carlos Martinez, Junhua Tao, Daniel Yazbeck
  • Efficient microbial preparation of capravirine metabolites M4 and M5
    Publication number: 20050043363
    Abstract: The present invention provides a method for producing metabolites of capravirine (2-carbamoyloxymethyl-5-(3,5-dichlorophenyl)thio-4-isopropyl-1-(4-pyridyl)methyl-1H-imidazole) via whole cell biotransformation using fungi and bacterial cells as oxygenation catalysts.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 24, 2005
    Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, Daniel Yazbeck