Patents by Inventor Shankar Rama

Shankar Rama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of aliskiren
    Patent number: 9090537
    Abstract: The present invention relates to an improved process for the preparation of pure compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: July 28, 2015
    Assignee: Mylan Laboratories Limited
    Inventors: Shankar Rama, Seshadri Rao Manukonda, Srinivasa Rao Dasari, Ramesh Dandala, Lakshmana Rao Vadali
  • PROCESS FOR THE PREPARATION OF ALISKIREN
    Publication number: 20150011793
    Abstract: The present invention relates to an improved process for the preparation of pure compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 8, 2015
    Applicant: MYLAN LABORATORIES LTD
    Inventors: Shankar Rama, Seshadri Rao Manukonda, Srinivasa Rao Dasari
  • Process for the preparation of tenofovir disoproxil fumarate
    Patent number: 8759515
    Abstract: The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: June 24, 2014
    Assignee: Mylan Laboratories Limited
    Inventors: Debashish Datta, Siva Rama Prasad Vellanki, Arabinda Sahu, Raja Babu Balusu, Mastan Rao Ravi, Hari Babu Nandipati, Shankar Rama, Lakshmana Rao Vadali, Srikanth Sarat Chandra Gorantla, Srinivasa Rao Dasari, Nagaraju Mittapelly
  • PROCESS FOR THE PREPARATION OF TENOFOVIR DISOPROXIL FUMARATE
    Publication number: 20130005969
    Abstract: The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.
    Type: Application
    Filed: March 11, 2011
    Publication date: January 3, 2013
    Inventors: Debashish Datta, Siva Rama Prasad Vellanki, Arabinda Sahu, Raja Babu Balusu, Mastan Rao Ravi, Hari Babu Nandipati, Shankar Rama, Lakshmana Rao Vadali, Srikanth Sarat Chandra Gorantla, Srinivasa Rao Dasari, Nagaraju Mittapelly
  • NOVEL PROCESS FOR THE PREPARATION OF CIS-NUCLEOSIDE DERIVATIVE
    Publication number: 20120295930
    Abstract: The present invention relates to an improved process for the preparation of cis-nucleoside derivative of formula-1 involving chlorination of the compound of formula-2 followed by reaction with compound of formula-3 in presence of a base to get compound of formula-4, reacting the compound of formula-4 with an alkyl halide (RiX) to get a quaternary ammonium salt then with cytosine derivative of formula-5 to provide the compound of formula-6, optionally de-protecting the compound of formula-6 to the compound of formula-7, reducing compound of formula-7 with metal catalyst in presence of a buffer solution, then adding an organic acid to get the compound of formula-8, and converting the compound of formula-8 to cis-nucleoside derivative of formula-1. The present invention further relates to novel cis-nucleoside derivative of formula-8. The present invention also relates to a pharmaceutical composition comprising cis-nucleoside derivative of formula-1 with excipients.
    Type: Application
    Filed: February 1, 2011
    Publication date: November 22, 2012
    Inventors: Shankar Rama, Sarat Chandra Srikanth Gorantla, Lakshmana Rao Vadali, Venkata Bala Kishore Sarma Inupakutika, Srinivas Rao Dasari, Nagaraju Mittapelly, Santosh Kumar Singh, Debashish Datta
  • PROCESS FOR THE PREPARATION OF LAMIVUDINE FORM I
    Publication number: 20100190982
    Abstract: The present invention provides a process for preparing a stable crystalline solid of Lamivudine polymorphic Form I, which does not change to Form II during storage and pharmaceutical unit operations.
    Type: Application
    Filed: September 1, 2008
    Publication date: July 29, 2010
    Inventors: Janardhana Rao Vascuri, Ravinder Reddy Vennapureddy, Shankar Rama, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • PROCESS FOR PREPARING PURINE DERIVATIVE
    Publication number: 20100137592
    Abstract: A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.
    Type: Application
    Filed: June 2, 2008
    Publication date: June 3, 2010
    Inventors: Asif Parvez Sayyed, Murali Krishna Ankaraju, Ravinder Reddy Vennapureddy, Shankar Rama, Ramesh Dandala, Sivakumaran Meenakshisunderam