Abstract: The present disclosure provides gene therapy expression constructs comprising a nucleic acid encoding a therapeutic anti-TNFalpha antibody (e.g., a monoclonal antibody) or an antigen binding fragment thereof, delivery vectors (e.g., viral vectors) comprising the same, compositions comprising the same, and methods of using the same (e.g., to treat ocular diseases or disorders). Some aspects of the disclosure are directed to a recombinant adeno-viral vector (rAAV) delivery comprising an AAV particle (e.g., AAV2) and a nucleic acid encoding a therapeutic anti-TNFalpha antibody (e.g., a monoclonal antibody) or an antigen binding fragment thereof.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disorder.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to wiring components in a component based application and provide a method, system and computer program product for heuristically assembling components in a component based application. In one embodiment, a data processing system configured to assemble component based applications can include a component aggregation application including an application builder configured to assemble components into a component based application. The system further can include a property broker coupled to the component aggregation application and configured to apply a wiring scheme to selected components in a component based application. Finally, a collaborative heuristic integration matching engine (CHIME) can be coupled to the property broker and a data store of behaviorally derived data, the CHIME including program enabled to suggest components for assembly in a component based application based upon behaviorally derived data in the data store.

Abstract: A method of providing annotations within a portal environment can include executing a portlet object having a tag, wherein the tag specifies an annotation service associated with an artifact presented by a graphical user interface of the portal environment. A visual identifier can be presented proximate to the artifact. The visual identifier can reference the annotation service. The method further can include creating an annotation using the annotation service responsive to the selection of the visual identifier.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disorder.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.

Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically high doses of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, with, an acetylcholinesterase inhibitor for the treatment of a neurodegenerative disease.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disorder.

Abstract: The present application relates to novel compositions useful for the treatment of a neurodegenerative disease and uses thereof. The present application also relates to novel compositions and methods for the reduction of side effects in a subject being treated for a neurodegenerative disease. The present application also relates to novel compositions and methods for enhancing the standard of care of the treatment of a neurodegenerative disease. The present application also relates to novel compositions and methods for enhancing the efficacy of one or more treatments for a neurodegenerative disease.

Abstract: Disclosed herein are compositions and methods for reducing the frequency of falls, improving balance, improving gait, or some combination thereof in subjects with neurodegenerative disease.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to wiring components in a component based application and provide a method, system and computer program product for heuristically assembling components in a component based application. In one embodiment, a data processing system configured to assemble component based applications can include a component aggregation application including an application builder configured to assemble components into a component based application. The system further can include a property broker coupled to the component aggregation application and configured to apply a wiring scheme to selected components in a component based application. Finally, a collaborative heuristic integration matching engine (CHIME) can be coupled to the property broker and a data store of behaviorally derived data, the CHIME including program enabled to suggest components for assembly in a component based application based upon behaviorally derived data in the data store.

Abstract: The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disorder.

Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, with other therapeutic agents for the treatment of a neurodegenerative disease.

Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically high doses of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, with, an acetylcholinesterase inhibitor for the treatment of a neurodegenerative disease.

Abstract: Embodiments of the present invention address deficiencies of the art in respect to wiring components in a component based application and provide a method, system and computer program product for heuristically assembling components in a component based application. In one embodiment, a data processing system configured to assemble component based applications can include a component aggregation application including an application builder configured to assemble components into a component based application. The system further can include a property broker coupled to the component aggregation application and configured to apply a wiring scheme to selected components in a component based application. Finally, a collaborative heuristic integration matching engine (CHIME) can be coupled to the property broker and a data store of behaviorally derived data, the CHIME including program enabled to suggest components for assembly in a component based application based upon behaviorally derived data in the data store.

Abstract: A method of providing annotations within a portal environment can include executing a portlet object having a tag, wherein the tag specifies an annotation service associated with an artifact presented by a graphical user interface of the portal environment. A visual identifier can be presented proximate to the artifact. The visual identifier can reference the annotation service. The method further can include creating an annotation using the annotation service responsive to the selection of the visual identifier.