Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: Disclosed is a power-optimized distributed arithmetic (DA)-based feed forward equalizer (FFE) that performs on-demand equalization processing of a data sample. Specifically, a data stream is represented by digital words, which indicate signal levels at taps on a transmission medium. A screener applies formulas to selected taps as opposed to all taps (e.g., to the main cursor tap, which corresponds to the current data sample, and to specific pre-cursor and post-cursor taps, which correspond to immediately proceeding and following data samples) to determine whether the current data sample (which should indicate a specific two-bit symbol) has degraded during transmission to a point where equalization processing is required. If so, a bypass flag is set to a first level so that the data sample is subjected to equalization processing. If not, the bypass flag is set to a second level so that such processing is bypassed. Also disclosed is a corresponding method.

Abstract: The present invention relates to an improved process for the preparation of Regorafenib with genotoxic impurities at well below threshold limit and high yield. The present invention also relates to an improved process for the preparation of regorafenib form-I with high purity.

Abstract: A data compression system includes a memory to store a plurality of predetermined prefixes corresponding to a plurality of classes of data. A classifying module is configured to receive data, receive a class of the data, and select a prefix to compress the data from the plurality of predetermined prefixes based on the data and the class of the data. A compressing module is configured to compress the data using the prefix. A header generating module is configured to generate a header including an indication of the prefix used to compress the data, and to output the header and the compressed data for storage or transmission. Using the prefix from the predetermined prefixes to compress the data eliminates an overhead of fetching the prefix from outside the data compression system.

Abstract: The present invention relates to an improved process for the preparation of Ibrutinib with high purity and high yields. The present process is cost effective and feasible in large scale production also. The present process avoids the mitsunobu reagent conditions also. The present Invention also relates to a process for the preparation of Crystalline form A and Crystalline form C of Ibrutinib.

Abstract: The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of preparing such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.

Abstract: The present invention provides a process for the preparation of crystalline anhydrous compound of Formula (X), Further, the present invention relates to the use of compound of Formula (X) preparation of Raltegravir (I) or its pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for performing backup and other secondary copy operations for large databases (e.g., “big data”), such as the Greenplum database, are described. In some cases, the systems and methods may maintain a second instance of a source database (e.g., Greenplum) using live synchronization (e.g., “Live Sync”), which performs incremental replication between a virtual machine containing a large database (e.g., a virtual machine containing a Greenplum database) and a synced copy of the virtual machine.

Abstract: The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of preparing such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.

Abstract: An illustrative data storage management system relies on a specially configured proxy server to operate software containers on a proxy server, maintain resources needed by the software containers, and interwork with other system components. Illustratively, a catalog service on the proxy server maintains a software cache according to maintenance rules and also maintains an associated cache catalog. The software containers are generally managed and operated by an illustrative container manager also hosted by the proxy server. The illustrative software cache comprises contents needed by the software containers, such as pre-configured container templates, DBMS software components, lightervisors representing target operating systems, and storage management software for performing test and storage operations. The maintenance rules govern when cache contents should be purged and moved into offline archive copies.

Abstract: The present invention relates to novel indazole compounds of the Formula (I), wherein, R1 is alkyl or cycloalkyl; (Formula II) including their stereoisomers and their pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-Hydroxy-tryptamine 4 (5-HT4) receptor agonists.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for managing a care team. For example, in one embodiment, care team members can be added to a care team using a manual approach, a semi-automated approach, or an automated approach. The care team can then be displayed simultaneously in a single view with the relevant relationships, roles, and responsibilities.

Abstract: The present invention provides a process for the preparation of crystalline anhydrous compound of Formula (X), Further, the present invention relates to the use of compound of Formula (X) preparation of Raltegravir (I) or its pharmaceutically acceptable salt thereof.

Abstract: An apparatus is provided for managing health care tasks. The apparatus may include at least one memory and at least one processor configured to display a user interface including a workspace area including visible indicia indicating steps of a health care task(s) to be performed on behalf of a patient(s) and a context area arranged adjacent to the workspace area. The context area includes visible information indicating health care data of the patient associated with visible indicia of the workspace area. The processor is also configured to update display of the visible indicia of the workspace area to include different health care data responsive to detecting a change in data of the visible indicia or updating display of the visible information of the context area to include different health care information responsive to detecting changes in information of the visible information. Corresponding computer program products and methods are also provided.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.

Abstract: A data storage management approach is disclosed that performs backup operations flexibly, based on a dynamic scheme of monitoring block changes occurring in production data. The illustrative system monitors block changes based on certain block-change thresholds and triggers block-level backups of the changed blocks when a threshold is passed. Block changes may be monitored in reference to particular files based on a reverse lookup mechanism. The illustrative system also collects and stores historical information on block changes, which may be used for reporting and predictive analysis.