Abstract: In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Abstract: A wireless network provides differentiated service via a first management device that manages and provisions resources that are located in an edge cloud of the wireless network separate from a second management device that manages and provisions resources that are located in a core cloud of the wireless network. The first management device may provision the edge cloud resources to provide various functionalities and services of the wireless network in a localized manner to user equipment (“UEs”) that are associated with low latency or high reliability requirements. The second management device may provision the core cloud resources to provide the same or different functionalities and services of the wireless network in a centralized manner to UEs that are not associated with low latency and high reliability requirements.

Abstract: A wireless network provides differentiated service via a first management device that manages and provisions resources that are located in an edge cloud of the wireless network separate from a second management device that manages and provisions resources that are located in a core cloud of the wireless network. The first management device may provision the edge cloud resources to provide various functionalities and services of the wireless network in a localized manner to user equipment (“UEs”) that are associated with low latency or high reliability requirements. The second management device may provision the core cloud resources to provide the same or different functionalities and services of the wireless network in a centralized manner to UEs that are not associated with low latency and high reliability requirements.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.

Abstract: Techniques described herein may allow for the selective enabling and/or disabling of shared access points (“SAPs”). The selective enabling and/or disabling may occur based on the analysis of key performance indicators (“KPIs”) associated with the SAPs. The selective enabling and/or disabling may cause the SAPs to cease (or continue) broadcasting their availability for User Equipment (“UEs”) of a particular wireless provider, decline (or accept) bearer requests for UEs of the particular wireless provider, or terminate existing connections with UEs of the particular wireless provider. The selective enabling and/or disabling may be performed for certain applications or Quality of Service (“QoS”) levels. The selective enabling and/or disabling may be performed proactively (e.g., without necessarily determining that the performance for a given SAP has not met a threshold performance), based on historical trends.

Abstract: A computer device may include a memory configured to store instructions and a processor configured to execute the instructions to select a base station; obtain one or more metric values for user equipment (UE) devices attached to the selected base station; and determine usage categories for at least some of the UE devices attached to the selected base station, wherein a usage category identifies a combination of a data type, a movement type, and a user type associated with a particular UE device. The processor may be further configured to execute the instructions to classify the obtained one or more metric values based on the determined usage categories; select one or more optimization actions for the selected base station based on the classified one or more metric values; and instruct the selected base station to perform the selected one or more optimization actions.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A computer device may include a memory configured to store instructions and a processor configured to execute the instructions to select a base station; obtain one or more metric values for user equipment (UE) devices attached to the selected base station; and determine usage categories for at least some of the UE devices attached to the selected base station, wherein a usage category identifies a combination of a data type, a movement type, and a user type associated with a particular UE device. The processor may be further configured to execute the instructions to classify the obtained one or more metric values based on the determined usage categories; select one or more optimization actions for the selected base station based on the classified one or more metric values; and instruct the selected base station to perform the selected one or more optimization actions.

Abstract: Techniques described herein may allow for the selective enabling and/or disabling of shared access points (“SAPs”). The selective enabling and/or disabling may occur based on the analysis of key performance indicators (“KPIs”) associated with the SAPs. The selective enabling and/or disabling may cause the SAPs to cease (or continue) broadcasting their availability for User Equipment (“UEs”) of a particular wireless provider, decline (or accept) bearer requests for UEs of the particular wireless provider, or terminate existing connections with UEs of the particular wireless provider. The selective enabling and/or disabling may be performed for certain applications or Quality of Service (“QoS”) levels. The selective enabling and/or disabling may be performed proactively (e.g., without necessarily determining that the performance for a given SAP has not met a threshold performance), based on historical trends.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the ?-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of ?-amyloid aggregates.

Abstract: Techniques described herein may allow for the selective enabling and/or disabling of shared access points (“SAPs”). The selective enabling and/or disabling may occur based on the analysis of key performance indicators (“KPIs”) associated with the SAPs. The selective enabling and/or disabling may cause the SAPs to cease (or continue) broadcasting their availability for User Equipment (“UEs”) of a particular wireless provider, decline (or accept) bearer requests for UEs of the particular wireless provider, or terminate existing connections with UEs of the particular wireless provider. The selective enabling and/or disabling may be performed for certain applications or Quality of Service (“QoS”) levels. The selective enabling and/or disabling may be performed proactively (e.g., without necessarily determining that the performance for a given SAP has not met a threshold performance), based on historical trends.

Abstract: A device may determine a set of characteristics of a network. The set of characteristics may relate to a set of wireless devices connected to the network. The device may alter a network configuration associated with a set of positioning reference signals (PRS signals) transmitted via the network based on the set of characteristics of the network. The alteration may relate to a characteristic of the set of PRS signals or a resource allocation for providing the set of PRS signals via the network. The device may transmit the set of PRS signals based on altering the network configuration to enable geolocation to be performed by the set of wireless devices connected to the network.

Abstract: To report feedback information regarding a wireless channel, a mobile station determines whether a predefined condition is satisfied. In response to determining that the predefined condition is satisfied, feedback information regarding an individual one of plural subbands of the wireless channel is included in a first report to be sent to a base station. In response to determining that the predefined condition is not satisfied, aggregate feedback information regarding the plural subbands is included in a second report to be sent to the base station.

Abstract: Techniques described herein may allow for the selective enabling and/or disabling of shared access points (“SAPs”). The selective enabling and/or disabling may occur based on the analysis of key performance indicators (“KPIs”) associated with the SAPs. The selective enabling and/or disabling may cause the SAPs to cease (or continue) broadcasting their availability for User Equipment (“UEs”) of a particular wireless provider, decline (or accept) bearer requests for UEs of the particular wireless provider, or terminate existing connections with UEs of the particular wireless provider. The selective enabling and/or disabling may be performed for certain applications or Quality of Service (“QoS”) levels. The selective enabling and/or disabling may be performed proactively (e.g., without necessarily determining that the performance for a given SAP has not met a threshold performance), based on historical trends.

Abstract: A computer device may include a memory configured to store instructions and a processor configured to execute the instructions to select a base station; obtain one or more metric values for user equipment (UE) devices attached to the selected base station; and determine usage categories for at least some of the UE devices attached to the selected base station, wherein a usage category identifies a combination of a data type, a movement type, and a user type associated with a particular UE device. The processor may be further configured to execute the instructions to classify the obtained one or more metric values based on the determined usage categories; select one or more optimization actions for the selected base station based on the classified one or more metric values; and instruct the selected base station to perform the selected one or more optimization actions.

Abstract: Techniques described herein relate to the dynamic modification of the serving band used by small cells in a heterogeneous network (HetNet) environment. The serving band may be modified to mitigate interference with macrocell eMBMS services. In various implementations, and based on scheduled eMBMS services, a small cell may switch the frequency band of the small cell, suspend service, and/or reduce the transmit power of the small cell.

Abstract: The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the ?-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of ?-amyloid aggregates.

Abstract: A device may determine a set of characteristics of a network. The set of characteristics may relate to a set of wireless devices connected to the network. The device may alter a network configuration associated with a set of positioning reference signals (PRS signals) transmitted via the network based on the set of characteristics of the network. The alteration may relate to a characteristic of the set of PRS signals or a resource allocation for providing the set of PRS signals via the network. The device may transmit the set of PRS signals based on altering the network configuration to enable geolocation to be performed by the set of wireless devices connected to the network.