Publication number: 20070155731
Abstract: Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Type:
Application
Filed:
January 26, 2005
Publication date:
July 5, 2007
Inventors:
Gabor Butora, Deodialsingh Guiadeen, Shankaran Kothandaraman, Malcolm MacCoss, Sander Mills, Lihu Yang
Publication number: 20060030582
Abstract: The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of a disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I: I (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
Type:
Application
Filed:
April 8, 2005
Publication date:
February 9, 2006
Inventors:
Julie DeMartino, Taro Akiyama, Mary Struthers, Lihu Yang, Joel Berger, Gregori Morriello, Alexander Pastemak, Changyou Zhou, Sander Mills, Gabor Butora, Shankaran Kothandaraman, Deodialsingh Guiadeen, Cheng Tang, Richard Jiao, Stephen Goble, Christopher Moyes
