Patents by Inventor Shanmugavel Mariappan

Shanmugavel Mariappan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the purification of (3R,4S)-4-(4-hydroxy-protected-phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
    Publication number: 20080058305
    Abstract: Provided are processes for purifying (3R,4S)-4-(4-hydroxyprotected-phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one having the following formula II wherein X and Y are hydrogen or a substituted or unsubstituted C1-8 alkyl; n is an integer between 0 and 3; and P is a hydroxyl protecting group. The Compound of formula II may be converted to an azetidinone compound, which is useful, for example, in reducing cholesterol in mammals.
    Type: Application
    Filed: April 10, 2007
    Publication date: March 6, 2008
    Inventors: Vinod Kumar Kansal, Suhail Ahmad, Sankaran Sethumadhavan, Shanmugavel Mariappan
  • Process for the synthesis of azetidinone
    Publication number: 20080032964
    Abstract: Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.
    Type: Application
    Filed: April 10, 2007
    Publication date: February 7, 2008
    Inventors: Vinod Kansal, Suhail Ahmad, Shanmugavel Mariappan, Bhupendra Tyagi, Nurit Perlman, Jacques Le Paih, Antonio Zanotti-Gerosa