Publication number: 20080038840
Abstract: The invention refers to compounds according to formula (I), wherein R1 is independently in position 2?, 3?, or in both positions of the A ring and is hydroxyl, linear or branched -0-alkyl, wherein the alkyl group has 1-12 carbon atoms, preferably 3-8, more preferably 4 carbon —O-(alkyl)COOH wherein the alkyl group has 1-12 carbon atoms, preferably 3-8, more preferably 4 carbon atoms, —O-(aryl)COOH, -0-aryl, linear or branched —O—(CH2)m—CH(NH2)—COOH with m=1-6, preferably m=2-4, or any combination thereof; R4 is in position 8?, 10?, or 11? of the D ring of the compound and is H or (CH2)n—CH3 with n=0-6, COOH, CN, or halogen, R5 and R6 independently are ethyl-, methyl-, H, or —(CH2)3 connected to position 8 or 10 of the D ring, and wherein provided that X is O, R2is F, Cl, Br, I, H, CN, —CH?CH-alkyl, —C?—C-alkyl, aryl and R3 is F, Cl, Br, I, CN, —CH?CH-alkyl, —C?C-alkyl, aryl an provided that X is S, R2 and R3 independently are F, Cl, Br, I, H, CN, —CH?CH-alkyl, —C?C-alkyl, aryl.
Type:
Application
Filed:
May 13, 2005
Publication date:
February 14, 2008
Applicant:
EUROPAEISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE
Inventors:
Carsten Schultz, Oliver Wichmann, Shannon Black