Patents by Inventor Shannon K. Hughes

Shannon K. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods involving Menain screening for inhibitors of cancer invasion and metastasis
    Patent number: 10928397
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: February 23, 2021
    Assignees: Massachusetts Institute of Technology, Albert Einstein College of Medicine
    Inventors: Frank B. Gertler, Shannon K. Hughes, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • MENAINV AND CANCER INVASION AND METASTASIS
    Publication number: 20190137501
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Application
    Filed: September 13, 2018
    Publication date: May 9, 2019
    Inventors: Frank B. Gertler, Shannon K. Hughes, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • Method of enhancing the efficacy of anti-hepatocyte growth factor receptor breast cancer therapy by administering an inhibitor of mena
    Patent number: 10114023
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: October 30, 2018
    Assignees: Massachusetts Institute of Technology, Albert Einstein College of Medicine, Inc.
    Inventors: Frank B. Gertler, Shannon K. Hughes-Alford, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING CANCER CELLS
    Publication number: 20170168056
    Abstract: The present disclosure provides methods of treatment and compositions for improving and determining the efficacy of anti-cancer therapies involving tubulin remodeling or protein tyrosine kinase activity by modulating and assaying the presence of certain Mena splicing isoforms.
    Type: Application
    Filed: November 14, 2016
    Publication date: June 15, 2017
    Inventors: Frank B. Gertler, Shannon K. Hughes, Madeleine J. Oudin, Douglas A. Lauffenburger
  • MENA AND ALPHA5 INTEGRIN INTERACTION
    Publication number: 20150079113
    Abstract: Methods are provided for treating invasion of a tumor or metastasis of a tumor in a subject comprising administering to the subject an agent which inhibits the interaction of Mena with an alpha5 integrin. Assays for identifying agents that inhibit interaction of Mena with an alpha5 integrin are also provided.
    Type: Application
    Filed: May 9, 2013
    Publication date: March 19, 2015
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Frank B. Gertler, Stephanie Gupton, Daisy Riquelme, Shannon K. Hughes-Alford, Madeleine J. Oudin
  • MENAINV AND CANCER INVASION AND METASTASIS
    Publication number: 20150044234
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Application
    Filed: April 12, 2013
    Publication date: February 12, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Frank B. Gertler, Shannon K. Hughes-Alford, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • Extruder with condenser
    Patent number: 6994533
    Abstract: A method and apparatus for producing microporous films. The method utilizes a casting surface and a condensing surface. The condensing surface is spaced from the casting surface to form a gap. The distance between the surfaces forming the gap is relatively small and is preferably less than 3 cm. A material, capable of forming microporous films through thermally induced phase separation processes, is cast onto the casting surface, preferably through conventional extrusion practices. The material contains at least one evaporative component that generally flashes off upon formation of the microporous material and condenses on the condensing surface.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 7, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Robert A. Yapel, Shannon K. Hughes, William Blake Kolb
  • Process of making microporous film
    Patent number: 6790404
    Abstract: A method and apparatus for producing microporous films. The method utilizes a casting surface and a condensing surface. The condensing surface is spaced from the casting surface to form a gap. The distance between the surfaces forming the gap is relatively small and is preferably less than 3 cm. A material, capable of forming microporous films through thermally induced phase separation processes, is cast onto the casting surface, preferably through conventional extrusion practices. The material contains at least one evaporative component that generally flashes off upon formation of the microporous material and condenses on the condensing surface.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: September 14, 2004
    Assignee: 3M Innovative Properties Company
    Inventors: Robert A. Yapel, Shannon K. Hughes, William Blake Kolb
  • Extrusion method and apparatus
    Publication number: 20020135087
    Abstract: A method and apparatus for producing microporous films. The method utilizes a casting surface and a condensing surface. The condensing surface is spaced from the casting surface to form a gap. The distance between the surfaces forming the gap is relatively small and is preferably less than 3 cm. A material, capable of forming microporous films through thermally induced phase separation processes, is cast onto the casting surface, preferably through conventional extrusion practices. The material contains at least one evaporative component that generally flashes off upon formation of the microporous material and condenses on the condensing surface.
    Type: Application
    Filed: September 21, 2001
    Publication date: September 26, 2002
    Applicant: 3M Innovative properties Company
    Inventors: Robert A. Yapel, Shannon K. Hughes, William Blake Kolb