Patents by Inventor Shanrong Zhang

Shanrong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
    Patent number: 6875419
    Abstract: The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R?, R? and R?? that are amides having a general formula: —CR1H—CO—NH—CH2—R2. R1 includes organic substituents and R2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R?, R? and R?? comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: April 5, 2005
    Assignee: Board of Regents The University of Texas System
    Inventors: A. Dean Sherry, Shanrong Zhang, Kuangcong Wu
  • pH sensitive MRI contrast agents
    Patent number: 6746662
    Abstract: A composition and method is disclosed for providing a magnetic resonance imaging contrast agent that is sensitive to pH, the compound and salts thereof including, a tetraaza base having a spacer at each of the amide groups, and a proton exchange attached to each of the spacer molecules, wherein the proton exchange group groups mediate proton exchange with water molecules that are trapped within the tetraaza base molecule.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: June 8, 2004
    Assignee: Board of Regents the University of Texas System
    Inventors: A. Dean Sherry, Shanrong Zhang, Kuangcong Wu
  • Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use
    Publication number: 20020127182
    Abstract: The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R′, R″ and R″′ that are amides having a general formula: —CR1H—CO—NH—CH2—R2. R1 includes organic substituents and R2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R′, R″ and R″′ comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula.
    Type: Application
    Filed: November 20, 2001
    Publication date: September 12, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: A. Dean Sherry, Shanrong Zhang, Kuangcong Wu