Patents by Inventor Shanthakumar R. Tyavanagimatt

Shanthakumar R. Tyavanagimatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ST-246 LIQUID FORMULATIONS AND METHODS
    Publication number: 20180185514
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 5, 2018
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove C. Bolken, Dennis E. HRUBY
  • AMORPHOUS TECOVIRIMAT PREPARATION
    Publication number: 20180125819
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Application
    Filed: January 2, 2018
    Publication date: May 10, 2018
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, N K Peter SAMUEL, Joseph PAZ, Ying TAN, Dennis E. HRUBY
  • ST-246 liquid formulations and methods
    Patent number: 9907859
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 6, 2018
    Assignee: Siga Technologies, Inc.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove′ C. Bolken, Dennis E. Hruby
  • Amorphous tecovirimat preparation
    Patent number: 9889119
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: February 13, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • Polymorphic forms of ST-246 and methods of preparation
    Patent number: 9744154
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: August 29, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A.C.L.S. Anderson, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
  • AMORPHOUS TECOVIRIMAT PREPARATION
    Publication number: 20170224661
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, N K Peter SAMUEL, Joseph PAZ, Ying TAN, Dennis E. HRUBY
  • Amorphous tecovirimat preparation
    Patent number: 9670158
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: June 6, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • REHYDRATION OF MICRONIZED TECOVIRMIMAT MONOHYDRATE
    Publication number: 20160235676
    Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
    Type: Application
    Filed: November 14, 2014
    Publication date: August 18, 2016
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Matthew Reeves, N K Peter SAMUEL, Steven PRIEBE, Ying TAN, Dennis E. HRUBY
  • Polymorphic forms of ST-246 and methods of preparation
    Patent number: 9339466
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: May 17, 2016
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. Stone, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
  • POLYMORPHIC FORMS OF ST-246 AND METHODS OF PREPARATION
    Publication number: 20160107993
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Application
    Filed: December 4, 2015
    Publication date: April 21, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
  • ST-246 LIQUID FORMULATIONS AND METHODS
    Publication number: 20160082128
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove' C. Bolken, Dennis E. HRUBY
  • ST-246 liquid formulations
    Patent number: 9233097
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: January 12, 2016
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. Stone, William C. Weimers, Gopi Krishna Kasi, Peter N. K. Samuel, Tove Bolken, Dennis E. Hruby
  • ST-246 Liquid Formulations and Methods
    Publication number: 20140011854
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Application
    Filed: August 2, 2011
    Publication date: January 9, 2014
    Applicant: Siga Technologies Inc.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A.C.L. Stone, William Weimers, Krishna Gopi Kasi, Peter N.K. Samuel, Tove' C. Bolken, Dennis E. Hruby
  • Polymorphic Forms of ST-246 and Methods of Preparation
    Publication number: 20110236434
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2011
    Publication date: September 29, 2011
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A.C.L. Stone, William C. Weimers, Dylan Nelson, Tove' C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan