Patents by Inventor Shantikumar Nair

Shantikumar Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250248926
    Abstract: Prolonged delivery of chemodrugs locally inside the brain with sufficient tissue-penetration is a critical requirement for treating various brain-diseases including malignant tumors. The present disclosure relates to an injectable microparticle system for brain-drug delivery. The injectable microparticle system comprising drug-loaded polymeric microparticles, wherein the drug-loaded polymeric microparticles are coated with an outer polymer gel layer enabling in-situ formation and releasing drug-polymer nanocomplexes of size <100 nm. The injectable microparticle system facilitates both deep tissue penetration for >2 cm as well as ‘sustained release’ of the drug for 15-30 days. The invention also discloses a method of producing said injectable microparticle system and the use of said injectable microparticle system in the treatment of brain tumor and other cancers.
    Type: Application
    Filed: July 4, 2023
    Publication date: August 7, 2025
    Applicant: AMRITA VISHWA VIDYAPEETHAM
    Inventors: Manzoor KOYAKUTTY, Devika DAS, Dhanya NARAYANAN, Ranjith RAMACHANDRAN, Shantikumar NAIR, Sreelakshmy JAYACHANDRAN
  • Publication number: 20250213497
    Abstract: The present invention relates to a nano-in micro formulation, capable of enhancing the oral bioavailability of drugs. Said formulation is made of a drug loaded composite nanoparticles made of protein-polymer, which is embedded within a microsystem (nano-in micro) made of multiple layers, each layer serving specific function such as enteric protection, muco-adhesion, muco-penetration, release modification, efflux inhibition, all functions collectively resulting in the enhanced bioavailability of loaded drug by at least two-fold when compared with control free drug. The present invention also discloses the process for conceiving said nano-in micro formulation and describes the use of said nano-in micro formulation in the treatment of cancer and other diseases.
    Type: Application
    Filed: March 29, 2023
    Publication date: July 3, 2025
    Inventors: MANZOOR KOYAKUTTY, LEKSHMI GOPAKUMAR, SHALIN CHAPPAN, MAYA SREERANGANATHAN, SHANTIKUMAR NAIR
  • Publication number: 20240335586
    Abstract: The present invention discloses a highly stretchable matrix, comprising mesh of lattice structures of microfibrillar filaments, having pore size enlargeable up to 8 times by moving the microfibrillar filaments perpendicular to the longitudinal axis of the microfibrillar filaments without losing its integrity. The invention also pertains to a method of preparing said highly stretchable matrix comprising the steps of: electrostatic spinning of the polymeric solution as microfibers, creating an air-flow at the inter-phase of microfibers to completely eliminate the solvent from the surface of the microfibers bundles to avoid inter-fibrillar bonding after collection and dispersing the microfibers in a direction perpendicular to the longitudinal axis of the fibers, 6-12 times the original width using a dispersion unit to obtain a stretch responsive fibrillar matrix.
    Type: Application
    Filed: August 2, 2022
    Publication date: October 10, 2024
    Inventors: Binulal Nelson Sathy, Shantikumar Nair, Niji Nandakumar
  • Publication number: 20230207894
    Abstract: The present invention relates to a rechargeable battery and a process near zero-energy regeneration of electrodes by recycling spent rechargeable batteries. The present invention relates to a process for near zero-energy regeneration of lithium iron phosphate (LiFePO4) or sodium iron phosphate (NaFePO4) cathode by recycling spent Lithium ferro phosphate rechargeable batteries.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 29, 2023
    Inventors: DHAMODARAN SANTHANAGOPALAN, SHANTIKUMAR NAIR, BINITHA GANGAJA
  • Publication number: 20220296714
    Abstract: The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle matrix material and incorporated therein in a quasi-aggregated state. The present invention further relates to methods for producing the invention nanoparticles, and to methods of killing cancer cells by PDT treatment using the said nanoparticles.
    Type: Application
    Filed: April 6, 2022
    Publication date: September 22, 2022
    Inventors: Manzoor Koyakutty, Dominic James Robinson, Henricus Johannes Cornelius Maria Sterenborg, Slavka Kascakova, Shantikumar Nair
  • Patent number: 11369681
    Abstract: The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1 KHz-1000 GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, immunotherapy, vascular or tumor embolization, and/or chemo/radio-embolization.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: June 28, 2022
    Assignee: Amrita Vishwa Vidyapeetham
    Inventors: Manzoor Koyakutty, Anusha Ashokan, Vijay Harish, Shantikumar Nair
  • Publication number: 20210059807
    Abstract: The present invention relates to woven tubular nanotextiles, fabrication thereof using a weaving apparatus, and use thereof in vascular graft applications. The woven nanotextile conduit is 0.1 to 50 mm in diameter and includes a multitude of hierarchically arranged nanofibers. They are made from low strength bundled nanoyarns containing thousands of nanofibers with improved mechanical strength. The weaving apparatus interweaves the warp and weft yarns in longitudinal and transverse directions, resulting in a flexible and strong woven product. The physical and biological properties of the woven nanotextile were significantly enhanced when compared to non-woven nanofibrous form and conventional medical textiles. The nanotextile displayed superhydrophilic behavior in an otherwise hydrophobic material and when implanted as a vascular graft was robust, suturable, kink-proof and non-thrombogenic, with complete endothelialization of the graft luminal area.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 4, 2021
    Inventors: DEEPTHY MENON, JOHN JOSEPH, PRAVEEN VARMA, SHANTIKUMAR NAIR
  • Patent number: 10806805
    Abstract: A composite implant for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant is formed of a calcium compound in the form of nano or microparticles doped with a first dopant configured to provide MRI contrast and a second dopant configured to provide CT contrast. The calcium compound is loaded onto a polymer gel matrix and lyophilized to form a mass with 3-dimensionally interconnected porosity, configured to provide tissue integration and proliferation sites. Methods of forming the composite implant are also disclosed. The implant could be a scaffold or bead structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: October 20, 2020
    Inventors: Manzoor Koyakutty, Sajesh K. Meethaleveedu, Anusha Ashokan, Vijay Harish Somasundaram, Shantikumar Nair
  • Publication number: 20190167822
    Abstract: The invention discloses non-iodinated radiopaque microbeads that may be used in image guided embolization in a subject ailing with tumor. The non-iodinated radiopaque microbeads include a ceramic material doped with a CT contrast agent or a MRI contrast agent or both. The doped ceramic is blended with a polymer and the blend is electrosprayed to form the radiopaque microbeads. Further the radiopaque microbeads are radiolabeled with a radioactive isotope. Methods of synthesis of the radiopaque microspheres are also disclosed. The non-iodinated radiopaque microbeads with radiolabeling are capable of rendering an imageable computed tomography (CT) contrast or magnetic resonance imaging (MRI) contrast when administered in a subject. Also the microspheres are biodegradable and hence the treatment could be repeated in case of recurrence of the tumor in the subject.
    Type: Application
    Filed: May 19, 2017
    Publication date: June 6, 2019
    Inventors: Manzoor KOYAKUTTY, Vijay Harish SOMASUNDARAM, Anusha ASHOKAN, Shantikumar NAIR
  • Publication number: 20190110883
    Abstract: The present invention relates to woven tubular nanotextiles, fabrication thereof using a weaving apparatus, and use thereof in vascular graft applications. The woven nanotextile conduit is 0.1 to 50 mm in diameter and includes a multitude of hierarchically arranged nanofibers. They are made from low strength bundled nanoyarns containing thousands of nanofibers with improved mechanical strength. The weaving apparatus interweaves the warp and weft yarns in longitudinal and transverse directions, resulting in a flexible and strong woven product. The physical and biological properties of the woven nanotextile were significantly enhanced when compared to non-woven nanofibrous form and conventional medical textiles. The nanotextile displayed superhydrophilic behavior in an otherwise hydrophobic material and when implanted as a vascular graft was robust, suturable, kink-proof and non-thrombogenic, with complete endothelialization of the graft luminal area.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Applicant: Amrita Vishwa Vidyapeetham
    Inventors: DEEPTHY MENON, JOHN JOSEPH, PRAVEEN VARMA, SHANTIKUMAR NAIR
  • Publication number: 20190076632
    Abstract: The invention discloses a saturable drug delivery implant made of a woven fabric material with variable packing density, dimension and weight. The woven fabric material includes electrospun continuous yarn with individual micro- or nano-fiber yarn made from a single polymer. The yarn is loaded with at least one therapeutic agent to provide controlled and sustained release when the device is sutured to a wall of the peritoneal cavity of a subject. The woven fabric is flexible, biodegradable and configured to be sutured to the wall of a body cavity to provide a sustained and controlled release of therapeutic agent in a subject. In some aspects, a peritoneal implant is sutured to the peritoneal wall cavity for continuous and sustained intraperitoneal release of a therapeutic agent.
    Type: Application
    Filed: September 14, 2018
    Publication date: March 14, 2019
    Inventors: DEEPTHY MENON, SMRITHI PADMAKUMAR, SHANTIKUMAR NAIR
  • Publication number: 20190054196
    Abstract: A composite implant for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant is formed of a calcium compound in the form of nano or microparticles doped with a first dopant configured to provide MRI contrast and a second dopant configured to provide CT contrast. The calcium compound is loaded onto a polymer gel matrix and lyophilized to form a mass with 3-dimensionally interconnected porosity, configured to provide tissue integration and proliferation sites. Methods of forming the composite implant are also disclosed. The implant could be a scaffold or bead structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.
    Type: Application
    Filed: March 3, 2017
    Publication date: February 21, 2019
    Inventors: MANZOOR KOYAKUTTY, SAJESH K. MEETHALEVEEDU, ANUSHA ASHOKAN, VIJAY HARISH SOMASUNDARAM, SHANTIKUMAR NAIR
  • Publication number: 20190000973
    Abstract: The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1 KHz-1000 GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, immunotherapy, vascular or tumor embolization, and/or chemo/radio-embolization.
    Type: Application
    Filed: December 5, 2016
    Publication date: January 3, 2019
    Applicants: Amrita Vishwa Vidyapeetham, DEPARTMENT OF BIOTECHNOLOGY
    Inventors: MANZOOR KOYAKUTTY, ANUSHA ASHOKAN, VIJAY HARISH, SHANTIKUMAR NAIR
  • Patent number: 10143700
    Abstract: A formulation for treating a patient with hepatocellular carcinoma is disclosed. The formulation comprises therapeutic agents in the form of nanoparticles containing one or more proteins or polysaccharides. The therapeutic agent is conjugated to an active targeting agent causing the formulation to preferentially segregate to the hepatocellular carcinoma tissue to release the therapeutic agents. Methods of treating hepatocellular carcinoma using the formulations are also disclosed.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 4, 2018
    Assignee: AMRITA VISHWA VIDYAPEETHAM
    Inventors: Manzoor Koyakutty, Giridharan Loghanathan Malarvizhi, Shantikumar Nair
  • Patent number: 10094051
    Abstract: Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: October 9, 2018
    Assignee: AMRITA VISHWA VIDYAPEETHAM
    Inventors: Deepthy Menon, John Joseph, Shantikumar Nair
  • Publication number: 20180274134
    Abstract: Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed.
    Type: Application
    Filed: May 30, 2018
    Publication date: September 27, 2018
    Applicant: Amrita Vishwa Vidyapeetham
    Inventors: DEEPTHY MENON, JOHN JOSEPH, SHANTIKUMAR NAIR
  • Patent number: 9994975
    Abstract: Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 12, 2018
    Inventors: Deepthy Menon, John Joseph, Shantikumar Nair
  • Publication number: 20170333365
    Abstract: A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
    Type: Application
    Filed: June 12, 2017
    Publication date: November 23, 2017
    Applicant: Amrita Vishwa Vidyapeetham
    Inventors: MANZOOR KOYAKUTTY, SHANTIKUMAR NAIR, ARCHANA P.RETNAKUMARI
  • Patent number: 9707186
    Abstract: A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: July 18, 2017
    Assignee: AMRITA VISHWA VIDYAPEETHAM
    Inventors: Manzoor Koyakutty, Shantikumar Nair, Archana P. Retnakumari
  • Publication number: 20170196811
    Abstract: A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, core-shell particle formulation configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enables treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 13, 2017
    Applicant: Amrita Vishwa Vidyapeetham
    Inventors: MANZOOR KOYAKUTTY, PARWATHY CHANDRAN, ARCHANA P.R., SHANTIKUMAR NAIR