Patents by Inventor Shanxiang Shen

Shanxiang Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors
    Patent number: 7141385
    Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: November 28, 2006
    Assignee: Protiveris, Inc.
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul, Sebastian Kossek, Gary W. Pace
  • Using complement component C1q derived molecules as tracers for fluorescence polarization assays
    Publication number: 20050208586
    Abstract: The present invention relates to polypeptides or non-polypeptides derived from C1q, a subunit of the first complement component molecule C1. These molecules bind to the C1q receptor on the Fc domain of an antibody in immune complexes (also called antigen-antibody complexes or aggregated immunoglobulins), but do not bind to free immunoglobulins. These complement component derived molecules may be used as tracer molecules for fluorescence polarization (FP). The present invention also relates to materials and methods of producing molecules for use in FP. The present invention has many applications in the areas of biosensor development for proteomics research, protein expression profiling, drug discovery, diagnosis and prognosis, monitoring therapeutic effects, environmental survey, and bio-defense.
    Type: Application
    Filed: March 18, 2004
    Publication date: September 22, 2005
    Inventor: Shanxiang Shen
  • Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors
    Publication number: 20040029108
    Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.
    Type: Application
    Filed: January 17, 2003
    Publication date: February 12, 2004
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul, Sebastian Kossek, Gary W. Pace
  • Microcantilever apparatus and methods for detection of enzymes
    Publication number: 20030068655
    Abstract: An apparatus and a method are provided for detecting an enzyme by measuring a change in defection of a microcantilever having a substrate for the enzyme.
    Type: Application
    Filed: September 12, 2001
    Publication date: April 10, 2003
    Applicant: Protiveris, Inc.
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul