Patents by Inventor Shaosong Chu

Shaosong Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALK kinase inhibitor, and preparation method and uses thereof
    Patent number: 10023593
    Abstract: An ALK kinase inhibitor compound as represented by Formula I, pharmaceutical composition containing the compound, and preparation method and use thereof in the preparation of drugs serving as an ALK inhibitor for treating cancer.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: July 17, 2018
    Assignee: Beijing Pearl Biotechnology Limited Liability Company
    Inventors: Jiaqiang Dong, Boyu Zhong, Hongbin Yuan, Chuan Shih, Shaosong Chu, Deyi Zhang, Ruihao Zhang
  • ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USES THEREOF
    Publication number: 20170247392
    Abstract: An ALK kinase inhibitor compound as represented by Formula I, pharmaceutical composition containing the compound, and preparation method and use thereof in the preparation of drugs serving as an ALK inhibitor for treating cancer.
    Type: Application
    Filed: May 29, 2015
    Publication date: August 31, 2017
    Inventors: Jiaqiang DONG, Boyu ZHONG, Hongbin YUAN, Chuan SHIH, Shaosong CHU, Deyi ZHANG, Ruihao ZHANG
  • PEPTIDE-DRUG CONJUGATES
    Publication number: 20170232023
    Abstract: Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.
    Type: Application
    Filed: January 27, 2017
    Publication date: August 17, 2017
    Inventor: Shaosong Chu
  • Peptide-drug conjugates
    Patent number: 9579317
    Abstract: Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: February 28, 2017
    Assignee: Jiarui Biopharmaceuticals, Ltd.
    Inventor: Shaosong Chu
  • PEPTIDE-DRUG CONJUGATES
    Publication number: 20150343083
    Abstract: Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.
    Type: Application
    Filed: June 1, 2015
    Publication date: December 3, 2015
    Inventor: Shaosong Chu
  • cMET inhibitors
    Patent number: 8178534
    Abstract: Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: May 15, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jerome C. Bressi, Shaosong Chu, Philip Erickson, Mallareddy Komandla, Lily Kwok, John D Lawson, Jeffrey A Stafford, Michael B. Wallace, Zhiyuan Zhang, Sanjib Das
  • cMET INHIBITORS
    Publication number: 20100063054
    Abstract: Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: August 14, 2009
    Publication date: March 11, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jerome C. Bressi, Shaosong Chu, Philip Erickson, Mallareddy Komandla, Lily Kwok, John D. Lawson, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang, Sanjib Das
  • PROTEIN KINASE INHIBITORS
    Publication number: 20090247501
    Abstract: Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases, and methods of using such compounds
    Type: Application
    Filed: March 3, 2009
    Publication date: October 1, 2009
    Applicant: Polaris Group
    Inventors: Shaosong Chu, Zhe Nie, Carin L. Perretta, Philip Eugene Erickson
  • Protein kinase inhibitors
    Patent number: 7517882
    Abstract: Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases, and methods of using such compounds.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 14, 2009
    Assignee: Polaris Group
    Inventors: Shaosong Chu, Zhe Nie, Carin L. Perretta, Philip Eugene Erickson
  • Protein Kinase Inhibitors
    Publication number: 20080070893
    Abstract: Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases, and methods of using such compounds
    Type: Application
    Filed: September 17, 2007
    Publication date: March 20, 2008
    Inventors: Shaosong Chu, Zhe Nie, Carin Perretta, Philip Erickson
  • Gyrase inhibitors
    Patent number: 6984652
    Abstract: Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: January 10, 2006
    Assignee: Warner-Lambert Company LLC
    Inventors: Kraig Yager, Shaosong Chu, Krzysztof Appelt, Xiaoming Li
  • Gyrase inhibitors
    Publication number: 20050250823
    Abstract: Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.
    Type: Application
    Filed: July 7, 2005
    Publication date: November 10, 2005
    Inventors: Kraig Yager, Shaosong Chu, Krzysztof Appelt, Xiaoming Li
  • Gyrase inhibitors
    Publication number: 20050054697
    Abstract: Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.
    Type: Application
    Filed: May 17, 2004
    Publication date: March 10, 2005
    Inventors: Kraig Yager, Shaosong Chu, Krzysztof Appelt, Xiaoming Li