Patents by Inventor Shaofeng RONG

Shaofeng RONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE SYNTHESIS OF PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20250101006
    Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.
    Type: Application
    Filed: January 30, 2023
    Publication date: March 27, 2025
    Inventors: Markus BAENZIGER, Fabrice GALLOU, Fengfeng GUO, Rudolf HÄNGGI, Enjian HAN, Guido JORDINE, Jialiang LI, Weipeng LIU, Bukeyan MIAO, Shaofeng RONG, Ernesto SANTANDREA, Paul Bernd SCHIRNER, Xiaodong SHEN, Can WANG, Hao ZHANG
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11578053
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: February 14, 2023
    Assignee: Novartis AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20220169630
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 2, 2022
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11208398
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 28, 2021
    Assignee: NOVARTIS AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20210269416
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 15, 2019
    Publication date: September 2, 2021
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN