Patents by Inventor Shaofeng Xie
Shaofeng Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220089033Abstract: The present invention relates to the technical field of train power supply and operation control, and provides a three-rail power supply control system for an electrical railway train. Power supply rails in the system are divided into a first power supply rail, a second power supply rail, and a third power supply rail, wherein the first power supply rail, the second power supply rail, and a running rail constitute a three-phase AC power supply loop, and the third power supply rail and the running rail constitute a DC power supply loop. An AC-DC-AC variable voltage variable frequency device supplies power to a train traction motor by means of the three-phase AC power supply loop and current collectors. Frequency modulation and voltage regulation power supply is conducted by means of the AC-DC-AC variable voltage variable frequency device on the ground to achieve train driving and operation control.Type: ApplicationFiled: June 27, 2019Publication date: March 24, 2022Inventors: Qunzhan LI, Kai GUO, Shaofeng XIE, Zihan LI, Xiaohong HUANG, Yuhua GUO, Shuqian LI, Bo WU
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Patent number: 9713616Abstract: Compositions comprising a calcium salt of L-leucovorin may be prepared that have a higher concentration of L-leucovorin than may be prepared using racemic leucovorin under similar conditions. Thus, some pharmaceutical compositions described herein may comprise a calcium salt of L-leucovorin at a relatively high concentration, such as at least about 15 mg/mL. Such a composition may be a stable aqueous solution, and may have near physiological pH, such as about 6 to about 8. Some pharmaceutical compositions may be substantially free of D-leucovorin, and may contain either: a) no EDTA, or b) less than about 1 mg/ml of EDTA. These compositions may be prepared, for example, by sonicating a mixture comprising the solid calcium salt of L-leucovorin and water. In some compositions, a calcium salt of L-leucovorin may be sufficiently soluble that it does not precipitate when it is injected.Type: GrantFiled: August 6, 2013Date of Patent: July 25, 2017Assignee: Spectrum Pharmaceuticals, Inc.Inventors: Pramod Kumar Gupta, Bahman Shimiaei, Shaofeng Xie
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Publication number: 20150164898Abstract: Compositions comprising a calcium salt of L-leucovorin may be prepared that have a higher concentration of L-leucovorin than may be prepared using racemic leucovorin under similar conditions. Thus, some pharmaceutical compositions described herein may comprise a calcium salt of L-leucovorin at a relatively high concentration, such as at least about 15 mg/mL. Such a composition may be a stable aqueous solution, and may have near physiological pH, such as about 6 to about 8. Some pharmaceutical compositions may be substantially free of D-leucovorin, and may contain either: a) no EDTA, or b) less than about 1 mg/ml of EDTA. These compositions may be prepared, for example, by sonicating a mixture comprising the solid calcium salt of L-leucovorin and water. In some compositions, a calcium salt of L-leucovorin may be sufficiently soluble that it does not precipitate when it is injected.Type: ApplicationFiled: August 6, 2013Publication date: June 18, 2015Inventors: Pramod Kumar Gupta, Bahman Shimiaei, Shaofeng Xie
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Patent number: 8795529Abstract: Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: GrantFiled: October 31, 2007Date of Patent: August 5, 2014Assignee: Dionex CorporationInventor: Shaofeng Xie
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Patent number: 7922909Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: GrantFiled: October 31, 2007Date of Patent: April 12, 2011Assignee: Dionex CorporationInventors: Robert W. Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Patent number: 7922908Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: GrantFiled: January 19, 2006Date of Patent: April 12, 2011Assignee: Dionex CorporationInventors: Robert W. Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Publication number: 20090184039Abstract: Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: ApplicationFiled: December 30, 2008Publication date: July 23, 2009Applicant: Dionex CorporationInventor: Shaofeng Xie
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Patent number: 7473367Abstract: Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: GrantFiled: August 10, 2005Date of Patent: January 6, 2009Assignee: Dionex CorporationInventor: Shaofeng Xie
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Publication number: 20080185327Abstract: Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: ApplicationFiled: October 31, 2007Publication date: August 7, 2008Applicant: Dionex CorporationInventor: Shaofeng Xie
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Publication number: 20080179773Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: ApplicationFiled: October 31, 2007Publication date: July 31, 2008Applicant: Dionex CorporationInventors: Robert W. Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Publication number: 20060207939Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: ApplicationFiled: January 19, 2006Publication date: September 21, 2006Inventors: Robert Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Patent number: 7074331Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: GrantFiled: June 25, 2003Date of Patent: July 11, 2006Assignee: Dionex CorporationInventors: Robert W. Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Publication number: 20050274662Abstract: Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: ApplicationFiled: August 10, 2005Publication date: December 15, 2005Applicant: Teledyne Isco, Inc.Inventor: Shaofeng Xie
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Publication number: 20050061745Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.Type: ApplicationFiled: August 6, 2004Publication date: March 24, 2005Applicant: Teledyne Isco, Inc.Inventors: Shaofeng Xie, Mingcheng Xu, Robert Allington
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Patent number: 6749749Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated.Type: GrantFiled: June 26, 2002Date of Patent: June 15, 2004Assignee: Isco, Inc.Inventors: Shaofeng Xie, Robert W. Allington
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Publication number: 20040020855Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.Type: ApplicationFiled: June 25, 2003Publication date: February 5, 2004Applicant: Isco, Inc.Inventors: Robert W. Allington, Shaofeng Xie, Tao Jiang, Mingcheng Xu
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Publication number: 20040000522Abstract: Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated.Type: ApplicationFiled: June 26, 2002Publication date: January 1, 2004Applicant: Isco, Inc.Inventors: Shaofeng Xie, Robert W. Allington