Patents by Inventor Shaogeng Tang

Shaogeng Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS RELATED TO A STRUCTURE OF HIGH-AFFINITY HUMAN PD-1/PD-L2 COMPLEX
    Publication number: 20210088528
    Abstract: Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.
    Type: Application
    Filed: April 28, 2020
    Publication date: March 25, 2021
    Inventors: Shaogeng Tang, Peter S. Kim
  • Methods related to a structure of high-affinity human PD-1/PD-L2 complex
    Patent number: 10684287
    Abstract: Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: June 16, 2020
    Assignees: Chan Zuckerberg Biohub, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shaogeng Tang, Peter S. Kim