Abstract: A pyridopyrimidinone derivative as represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof or a prodrug thereof. The pyridopyrimidinone derivative has a good SOS1 inhibitory effect.

Abstract: A UV/O3/H2O2 advanced oxidation reactor includes a water inlet pipe, a water outlet pipe, an ultraviolet reactor, an H2O2 adding device and an O3 adding device. The ultraviolet reactor has a plurality of ultraviolet lamps embedded therein, and the ultraviolet lamps are arranged at an angle with respect to partition plates. The water inlet pipe is connected to a water inlet in a lower portion of the ultraviolet reactor, and the water outlet pipe is connected to a water outlet in an upper portion of the ultraviolet reactor. The H2O2 adding device and the O3 adding device are arranged on a connecting pipe of the water inlet pipe. After raw water is pressurized, H2O2 is added into the raw water through the H2O2 adding device, then ozone is added in the raw water through a water injector, and finally the raw water enters the ultraviolet reactor.

Abstract: The present disclosure provides a coal bump control method for sectional hydraulic fracturing regions of a near vertical ultra thick coal seam. The method includes: deepening a main shaft from a mining level to a fracturing level; excavating a cross-hole from a roof rock layer of a coal seam at the fracturing level to enter a coal seam being mined, and excavating a roadway along the strike of the coal seam; and drilling hydraulic fracturing boreholes in a dedicated fracturing roadway along an inclination angle of the coal seam to the coal seam above the roadway, wherein the length of the borehole makes the borehole in communication with a goaf, and the spacing of the boreholes along the strike and the sectional spacing of the boreholes in an inclination direction are designed according to the parameters of fracturing equipments and the fracturing length.

Abstract: A binder includes a polymer and ceramic particles modified with silane coupling agent. The polymer contains structural units derived from a first-type monomer, a second-type monomer, and a third-type monomer, and a molar ratio of the first-type monomer, the second-type monomer, and the third-type monomer is (50 to 58):(40 to 44):(2 to 6). The first-type monomer is selected from one or more compounds of formula I, the second-type monomer is selected from one or more compounds of formula II, and the third-type monomer is selected from one or more compounds of formula III.

Abstract: This application relates to the field of lithium battery technologies, and in particular, to a binder, a separator, and a lithium-ion battery using such separator, where the binder includes a terpolymer formed by copolymerization of a first monomer unit, a second monomer unit, and a third monomer unit that are specified.

Abstract: The present disclosure provides a coal bump control method for sectional hydraulic fracturing regions of a near vertical ultra thick coal seam. The method includes: deepening a main shaft from a mining level to a fracturing level; excavating a cross-hole from a roof rock layer of a coal seam at the fracturing level to enter a coal seam being mined, and excavating a roadway along the strike of the coal seam; and drilling hydraulic fracturing boreholes in a dedicated fracturing roadway along an inclination angle of the coal seam to the coal seam above the roadway, wherein the length of the borehole makes the borehole in communication with a goaf, and the spacing of the boreholes along the strike and the sectional spacing of the boreholes in an inclination direction are designed according to the parameters of fracturing equipments and the fracturing length.

Abstract: A UV/O3/H2O2 advanced oxidation reactor includes a water inlet pipe, a water outlet pipe, an ultraviolet reactor, an H2O2 adding device and an O3 adding device. The ultraviolet reactor has a plurality of ultraviolet lamps embedded therein, and the ultraviolet lamps are arranged at an angle with respect to partition plates. The water inlet pipe is connected to a water inlet in a lower portion of the ultraviolet reactor, and the water outlet pipe is connected to a water outlet in an upper portion of the ultraviolet reactor. The H2O2 adding device and the O3 adding device are arranged on a connecting pipe of the water inlet pipe. After raw water is pressurized, H2O2 is added into the raw water through the H2O2 adding device, then ozone is added in the raw water through a water injector, and finally the raw water enters the ultraviolet reactor.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining an adjusted requirement for transmission of a given digital component. In one aspect, a system includes a damping subsystem that obtains, from an evaluation subsystem, a standard requirement for transmission of the given digital component. The damping subsystem also obtains, from a prediction subsystem, a predicted requirement for transmission of the given digital component. The damping subsystem determines whether a damping condition is met. When the damping condition is met, the damping subsystem determines the adjusted requirement based on at least the predicted requirement. When the damping condition is not met, the damping subsystem determines the adjusted requirement based on at least the standard requirement.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium.

Abstract: Methods and systems are provided for a question answering. In some implementations, a data element to be updated is identified in a knowledge graph and a query is generated based at least in part on the data element. The query is provided to a query processing engine. Information is received from the query processing engine in response to the query. The knowledge graph is updated based at least in part on the received information.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium.

Abstract: Methods and systems are provided for a question answering. In some implementations, a data element to be updated is identified in a knowledge graph and a query is generated based at least in part on the data element. The query is provided to a query processing engine. Information is received from the query processing engine in response to the query. The knowledge graph is updated based at least in part on the received information.

Abstract: A Learning Enhanced Simulated Annealing (LESA) method is provided. Based on a Simulated Annealing (SA) framework, this method adds a Knowledge Base (KB) initialized at the beginning of the search and updated at each iteration, which memorizes a portion of the search history and guides the further search through a KB trial generator. The basic idea of LESA is that its search history is stored in a KB, and a KB trial generator extracts information from it and uses it to generate a new trial. The next move of the search is the weighted sum of the trial generated by the KB trial generator and the trial generated by the usual SA trial generator. The knowledge base is then updated after each search iteration.

Abstract: A nodule registration system useful for tracking lung nodules in computed tomography (CT) scans is presented. The system registers a small sphere centered on a detected nodule in one scan with another scan under a rigid transformation assumption using a fast registration scheme. The registration scheme employs very fast simulated annealing (VFSA) with constraints to maximize a tunable cross-correlation (TCC) coefficient, enabling the system to register, with minimal registration error, all nodules within their maximum diameter. The system achieves an average registration time of 10 seconds or less on a 3.06 GHz computer programmed to implement the present invention.

Abstract: A nodule registration system useful for tracking lung nodules in computed tomography (CT) scans is presented. The system registers a small sphere centered on a detected nodule in one scan with another scan under a rigid transformation assumption using a fast registration scheme. The registration scheme employs very fast simulated annealing (VFSA) with constraints to maximize a tunable cross-correlation (TCC) coefficient, enabling the system to register, with minimal registration error, all nodules within their maximum diameter. The system achieves an average registration time of 10 seconds or less on a 3.06 GHz computer programmed to implement the present invention.

Abstract: A Learning Enhanced Simulated Annealing (LESA) method is provided. Based on a Simulated Annealing (SA) framework, this method adds a Knowledge Base (KB) initialized at the beginning of the search and updated at each iteration, which memorizes a portion of the search history and guides the further search through a KB trial generator. The basic idea of LESA is that its search history is stored in a KB, and a KB trial generator extracts information from it and uses it to generate a new trial. The next move of the search is the weighted sum of the trial generated by the KB trial generator and the trial generated by the usual SA trial generator. The knowledge base is then updated after each search iteration.