Patents by Inventor Shaohua Xu
Shaohua Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240105351Abstract: A method for measuring drop time of a control rod cluster integrated with a rod position measurement device is provided, wherein the method is used to measure the drop time of each control rod cluster, and includes: Si, monitoring a voltage Ua of coils in Group A to capture a rod cluster drop signal; S2, searching a point (tmax, Vmax) with a maximum drop speed or with a local maximum drop speed; S3, retroactively calculating, from tmax, an end of a time period T4 when the control rod cluster starts to drop; S4, retroactively searching, from a minimum value point of a drop reference signal DROPref, a start of the time period T4 when the drop reference signal DROPref drops from a maximum value to 33% thereof; and S5, determining, from tmax forward, a time point t6 when a drop speed of the control rod cluster is lower than 0.Type: ApplicationFiled: January 14, 2021Publication date: March 28, 2024Applicant: NUCLEAR POWER OPERATIONS RESEARCH INSTITUTE (NPRI)Inventors: Zhengke CHANG, Minghui ZHANG, Yuan HUANG, Ye TIAN, Shaohua XU, Xinxin LIU, Weijian ZHU, Yiming MA, Shengfeng XU, Bo CHAO, Ning TAO, Zihua YANG, Desong LANG, Qichao WANG
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Publication number: 20240073287Abstract: Embodiments of the present disclosure provide a method for activating at least a first edge server and a second edge server. The first edge server includes a first service processor, and the second edge server includes a second service processor. The method includes establishing a data communication connection between the first service processor and the second service processor, establishing a data communication connection between the first service processor and a specified website, establishing a trusted communication between the first service processor and the specified website, establishing a trusted communication between the first service processor and the second service processor, obtaining an activation right from the specified website by the first service processor, and performing the activation right to activate the first edge server and the second edge server by the first service processor.Type: ApplicationFiled: August 31, 2023Publication date: February 29, 2024Inventors: Ming LEI, Haijun XU, Zhipeng GAO, Da LI, Shaohua LI
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Patent number: 11827672Abstract: Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.Type: GrantFiled: March 29, 2019Date of Patent: November 28, 2023Assignee: Eureka Therapeutics, Inc.Inventors: Jun Cui, Pengbo Zhang, Yiyang Xu, Shan Li, Yixiang Xu, Guangyan Xiong, Hongruo Yun, Lianxing Liu, Xiaomei Ge, Shaohua Xu, Hong Liu, Javier Morales
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Patent number: 11508487Abstract: A full-digital control rod position measurement device and a method thereof. The full-digital rod position measurement device transforms the core process of rod position measurement that is normally processed by an analog circuit or analog-to-digital mixed circuit into a digital processing. The full-digital rod position measurement device comprises an excitation power supply, an integrated interface board, and a universal signal processor. The universal signal processor processes output signals of detectors according to a preset numerical processing algorithm and outputs Gray code rod position signals. The full-digital rod position measurement device and method disclosed by the present disclosure may effectively reduce the complexity of the primary excitation circuit and the secondary measurement signal processing circuit of the detectors, and improve the operation reliability and measurement accuracy of the rod position processing equipment.Type: GrantFiled: October 30, 2017Date of Patent: November 22, 2022Assignee: CNNC NUCLEAR POWER OPERATION MANAGEMENT CO., LTDInventors: Zhengke Chang, Long Yu, ShengFeng Xu, ShaoHua Xu, Bo Chao, Fei Xu, Peng Zhao, Yuan Huang, Chengguang Yuan
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Publication number: 20220323497Abstract: Described herein are immune cells comprising: a chimeric antigen receptor (CAR) that comprises (i) an extracellular target-binding domain comprising an antibody moiety; (ii) a transmembrane domain; and (iii) a primary signaling domain, and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or compositions thereof for therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).Type: ApplicationFiled: July 24, 2020Publication date: October 13, 2022Inventors: Hongruo YUN, Jun Cui, Pengbo Zhang, Yiyang Xu, Lucas Horan, Shaohua Xu, Guangyan Xiong, Shan Li, Yixiang Xu, Bradley Austin Heller, Hongbing Zhang, Hong Liu
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Publication number: 20220267420Abstract: Provided herein are compositions, kits, and methods for manufacturing cells for adoptive cell therapy comprising (a) an engineered receptor, vector encoding an engineered receptor, or engineered immune cell expressing such engineered receptor or comprising such vector; and (b) a Fox P3 targeting agent.Type: ApplicationFiled: February 14, 2019Publication date: August 25, 2022Applicants: Memorial Sloan Kettering Cancer Center, Eureka Therapeutics, Inc.Inventors: David A. SCHEINBERG, Cheng LIU, Zhiyuan YANG, Lianxing LIU, Shaohua Xu, Pei WANG, Yiyang XU
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Publication number: 20220265715Abstract: Described herein are chimeric antigen receptors (CARs) comprising an extracellular target-binding domain comprising an antibody moiety (e.g., a single chain variable fragment (scFv) antibody), a transmembrane domain, a CD30 costimulatory domain, and a primary signaling domain. Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).Type: ApplicationFiled: July 24, 2020Publication date: August 25, 2022Inventors: Hongruo YUN, Jun Cui, Pengbo Zhang, Yiyang Xu, Lucas Horan, Shaohua Xu, Guangyan Xiong, Shan LI, Yixiang Xu, Hong Liu
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Publication number: 20210017280Abstract: Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Inventors: Jun CUI, Pengbo Zhang, Yiyang Xu, Shan Li, Yixiang Xu, Guangyan Xiong, Hongruo Yun, Lianxing Liu, Xiaomei Ge, Shaohua Xu, Hong Liu, Javier Morales
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Publication number: 20200258643Abstract: A full-digital control rod position measurement device and a method thereof. The full-digital rod position measurement device transforms the core process of rod position measurement that is normally processed by an analog circuit or analog-to-digital mixed circuit into a digital processing. The full-digital rod position measurement device comprises an excitation power supply, an integrated interface board, and a universal signal processor. The universal signal processor processes output signals of detectors according to a preset numerical processing algorithm and outputs Gray code rod position signals. The full-digital rod position measurement device and method disclosed by the present disclosure may effectively reduce the complexity of the primary excitation circuit and the secondary measurement signal processing circuit of the detectors, and improve the operation reliability and measurement accuracy of the rod position processing equipment.Type: ApplicationFiled: October 30, 2017Publication date: August 13, 2020Inventors: Zhengke CHANG, Long YU, ShengFeng XU, ShaoHua XU, Bo CHAO, Fei XU, Peng ZHAO, Yuan HUANG, Chengguang YUAN
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Patent number: 7970476Abstract: Movement of a freely roaming animal (190), such as a rat, is guided using electric stimulation of the animal's brain. Cues are provided to the animal to move forward by stimulating a reward center of the brain. Cues are provided to the animal to change its direction by stimulating portions of the animal's brain that control right and left movements, such as a cortical representation of whiskers of the animal. Multi-channel, remotely controlled equipment (140, 145, 150, 350) may be carried by the animal to enable independent energizing of electrodes attached to different regions of the animal's brain. A transmitter carried by the animal may report back data to allow monitoring. A component may be carried by the animal for carrying out a mission, such as for search and rescue or surveillance. Groups of animals may be controlled in real-time by coordinating their movements and tracking their locations.Type: GrantFiled: February 10, 2003Date of Patent: June 28, 2011Assignee: The Research Foundation of the State University of New YorkInventors: John K. Chapin, Sanjiv K. Talwar, Shaohua Xu, Emerson S. Hawley
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Publication number: 20030199944Abstract: Movement of a freely roaming animal (190), such as a rat, is guided using electric stimulation of the animal's brain. Cues are provided to the animal to move forward by stimulating a reward center of the brain. Cues are provided to the animal to change its direction by stimulating portions of the animal's brain that control right and left movements, such as a cortical representation of whiskers of the animal. Multi-channel, remotely controlled equipment (140, 145, 150, 350) may be carried by the animal to enable independent energizing of electrodes attached to different regions of the animal's brain. A transmitter carried by the animal may report back data to allow monitoring. A component may be carried by the animal for carrying out a mission, such as for search and rescue or surveillance. Groups of animals may be controlled in real-time by coordinating their movements and tracking their locations.Type: ApplicationFiled: February 10, 2003Publication date: October 23, 2003Inventors: John K. Chapin, Sanjiv K. Talwar, Shaohua Xu, Emerson S. Hawley
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Patent number: 5874668Abstract: An atomic force microscope for quantitative imaging and identification, at the molecular or submolecular level, biomolecules or subunits of biomolecules in a physiologic environment, through use of a cantilever tip incorporating a biomolecular identifier.Type: GrantFiled: October 24, 1995Date of Patent: February 23, 1999Assignee: Arch Development CorporationInventors: Shaohua Xu, Morton F. Arnsdorf