Abstract: A novel vaccine and methods of preventing and treating C. difficile infection in a patient is described. The vaccine is comprised of at least a portion of receptor binding domain 2 (RBD2) protein or a protein comprising at least a portion of receptor binding domain 1 (RBD1) protein and RBD2 protein (RBD1+2) from binary toxin (CDT) of C. difficile. Administration of the vaccine, as well as anti-RBD2 or anti-RBD1+2 serum, has been shown to prevent C. difficile infection as well as treat existing infections.

Abstract: Provided are a compound for recovering a p53 mutation function and use thereof, particularly relating to a compound represented by Formula M, or an enantiomer, a diastereomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a crystal form, a nitrogen oxide, a metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug of the compound.

Abstract: The present application provides a compound as shown in formula (0), a pharmaceutical composition containing same, a synthesis method therefore and a use thereof. The compound of the present application can significantly reduce the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that the protein in the cells tends to be synthesized normally, providing more possible drugs for ISR pathway-mediated diseases or condition eIF2B-related diseases, and/or diseases related to regulation of the activity or level of eIF2B activity or level, and regulation of the activity or level of the eIF2 pathway or ISR pathway.

Abstract: Provided in the present application is a compound as represented by formula (1). The compound can regulate the KIF18A protein, thereby affecting the cell cycle and the cell proliferation process to treat cancer and cancer-associated diseases. The present disclosure further comprises a pharmaceutical composition containing the compound, and a method for treating conditions associated with the KIF18A activity.

Abstract: Provided are a compound of formula 0, a stereoisomer thereof, a tautomer thereof, a geometric isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, an N-oxide thereof, an isotopically labeled compound thereof, a metabolite thereof, an ester thereof, a prodrug thereof, and a pharmaceutically acceptable salt thereof. In formula 0, ring B is a 5- to 10-membered spiro ring or a 5- to 10-membered spiro heterocyclic ring. The 5- to 10-membered spiro ring and the 5- to 10-membered spiro heterocyclic ring are optionally substituted with 1-5 R1F. The compound can significantly weaken the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that proteins in the cells tend to be synthesized normally.

Abstract: The present application relates to a compound for inhibiting IRAK4 activity and a use thereof, and specifically provides a compound as represented by formula A, or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt, an ester, a solvate, a hydrate, an isotope-labeled compound (preferably a deuterated substance), or a prodrug thereof,

Abstract: The present application provides a compound as shown in formula (0), a pharmaceutical composition containing same, a synthesis method therefore and a use thereof. The compound of the present application can significantly reduce the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that the protein in the cells tends to be synthesized normally, providing more possible drugs for ISR pathway-mediated diseases or condition eIF2B-related diseases, and/or diseases related to regulation of the activity or level of eIF2B activity or level, and regulation of the activity or level of the eIF2 pathway or ISR pathway.

Abstract: A hydrosilylation curable textile coating composition comprises: (a) a linear organopolysiloxane polymer having at least two alkenyl and/or alkynyl groups per molecule; (b) a reinforcing filler comprising at least one of fumed silica, precipitated silica, or calcium carbonate; (c) a linear trimethyl terminated polydimethyl methylhydrogen siloxane containing at least two silicon-bonded hydrogen groups per molecule; (d) a hydrosilylation cure catalyst; (e) an organosilicon resin; and (f) an adhesion promoter comprising a mixture and/or reaction product of: (i) one or more alkoxysilanes having an epoxy group in the molecule; (ii) a linear organopolysiloxane oligomer containing at least one alkenyl group and at least one hydroxy or alkoxy group per molecule; and (iii) an organometallic condensation reaction catalyst comprising organoaluminum or organozirconium compounds.

Abstract: The present disclosure relates to methods and compositions to treat or prevent Clostridioides difficile infection or recurrence.

Abstract: Provided herein is a self-lubricating silicone elastomer composition and a self-lubricating, elastomeric material made therefrom which has a low coefficient of friction and avoids the need for “self-bleeding”. The self-lubricating silicone elastomer composition comprises: (i) 50 to 75% by weight of one or more polydiorganosiloxane polymer(s) containing from 0.01 to 0.1% by weight of alkenyl and/or alkynyl content; (ii) 3 to 15% by weight of a polydiorganosiloxane polymer having ?0.5% by weight of alkenyl or alkynyl content; (iii) 10 to 35% by weight of reinforcing filler; and either or both of (iv) a peroxide catalyst; or (v) a hydrosilylation catalyst package.

Abstract: Disclosed in the present invention are a glutarimide compound, and the use thereof. Specifically disclosed are a compound as represented by formula (VII-0) and a pharmaceutically acceptable salt thereof.

Abstract: Provided are a 2,6-piperidinedione compound and an application thereof. Particularly provided are a compound represented by formula (II), a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.

Abstract: A PTFE composite powder, a preparation method thereof, and a composite material containing the same are provided. The PTFE composite powder includes the following components: a PTFE powder, an inorganic powder, and a surface treatment agent. The inorganic powder is coated on a surface of the PTFE powder to form an inorganic powder layer, and the surface treatment agent is coated on the inorganic powder layer. For the composite material obtained by the present invention, the compatibility between the PTFE composite powder and matrix polymer is better than that of the prior art, leading to larger addition amount, and smaller dielectric constant and dielectric loss of the composite material, thus suitable for being used as 5G materials.

Abstract: Addition curing electrically conductive liquid silicone rubber (LSR) compositions, their methods of preparation, and cured elastomeric products made from the compositions are provided. The compositions are cured to form elastomeric products suitable for high voltage applications such as cable joints, cable terminal applications, cable accessories and connectors. In general, the composition comprises: (a) at least one polydiorganosiloxane having at least two alkenyl groups per molecule: (b) at least one organohydrogenpolysiloxane: (c) at least one reinforcing filler: (d) at least one hydrosilylation catalyst: and (e) an electrically conductive filler. Component (e) comprises: (i) extra conductive carbon black: and (ii) single walled carbon nanotubes.

Abstract: The invention provides a sampling device for geological fluid detection, relates to the technical field of fluid detection. The sampling device comprises a support frame, the support frame is of an L-shaped structure, and a second support plate is arranged at an upper portion of the support frame; the protection cover is mounted at the corner of a bottom portion of the support frame. The water fixing member is clamped above the bottom portion of the support frame; the locking inclined block is mounted at the bottom portion of the; and the detector is provided with a water inlet pipe. Fluid at different depths is detected through cooperation of the mounting sleeve and the lifting frame, a fluid drainage tube is wound around the winding wheel, the mounting sleeve is driven by the lifting frame to adjust the position through the arrangement of the gear and the rack, the fluid is sampled through the sampling test tube.

Abstract: A class of 1,7-naphthyridine compounds and an application thereof, the compounds being compounds represented by formula (II) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a multifunctional rock mechanics tester, pertaining to the technical field of mechanics tester, consisting of a base; wherein a power mechanism is mounted on the top of the base, two tension testing mechanisms are arranged on the power mechanism in an up-and-down symmetrical way, a clamping mechanism is mounted on each tension testing mechanism, a rock testing block is clamped between the two clamping mechanisms. The present invention realizes the tension and pressure testing of the rock test block through the arrangement of tension testing mechanism and pressure testing mechanism, thus improving the functionality of the present mechanics tester, which not only reduces the testing cost, but also effectively decreases the occupied space; the present invention solves the problem that the traditional mechanics tester can only complete one kind of test when it is used.

Abstract: Disclosed is a multi-shaft pressurized rock mechanics tester, pertaining to the technical field of rock mechanics testing devices, comprising a base; the base is of an integral rectangular structure, and welded six vertical support plates symmetrically at the front and back ends, a -shaped bracket plate is horizontally welded at the top of the six vertical support plates (“” is a Chinese character, read as “Ri”), and a bracket plate is rotatably installed on the top section of the three rear vertical support plates, pressed against the -shaped bracket plate; the left and right sides of the base are symmetrically welded with four vertical bracing plates, an I-shaped installation plate is welded on the top of the four vertical bracing plates, four hydraulic cylinders are locked, fixed and hoisted on the bottom of the I-shaped installation plate with screws.

Abstract: Disclosed is a multi-shaft pressurized rock mechanics tester, pertaining to the technical field of rock mechanics testing devices, comprising a base; the base is of an integral rectangular structure, and welded six vertical support plates symmetrically at the front and back ends, a -shaped bracket plate is horizontally welded at the top of the six vertical support plates (“” is a Chinese character, read as “Ri”), and a bracket plate is rotatably installed on the top section of the three rear vertical support plates, pressed against the -shaped bracket plate; the left and right sides of the base are symmetrically welded with four vertical bracing plates, an I-shaped installation plate is welded on the top of the four vertical bracing plates, four hydraulic cylinders are locked, fixed and hoisted on the bottom of the I-shaped installation plate with screws.

Abstract: The present invention provides a multifunctional rock mechanics tester, pertaining to the technical field of mechanics tester, consisting of a base; wherein a power mechanism is mounted on the top of the base, two tension testing mechanisms are arranged on the power mechanism in an up-and-down symmetrical way, a clamping mechanism is mounted on each tension testing mechanism, a rock testing block is clamped between the two clamping mechanisms. The present invention realizes the tension and pressure testing of the rock test block through the arrangement of tension testing mechanism and pressure testing mechanism, thus improving the functionality of the present mechanics tester, which not only reduces the testing cost, but also effectively decreases the occupied space; the present invention solves the problem that the traditional mechanics tester can only complete one kind of test when it is used.