Patents by Inventor Shaojiang Deng

Shaojiang Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
    Patent number: 9409892
    Abstract: The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: August 9, 2016
    Assignee: FibroGen, Inc.
    Inventors: Wen-Bin Ho, Hongda Zhao, Shaojiang Deng, Danny Ng, Lee R. Wright, Min Wu, Xiaoti Zhou, Michael P. Arend, Lee A. Flippin
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20160009653
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoictin-associated conditions.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 14, 2016
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Cyanoisoquinoline compounds and methods of use thereof
    Patent number: 9174976
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 3, 2015
    Assignee: FIBROGEN, INC.
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS
    Publication number: 20150038528
    Abstract: The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 5, 2015
    Inventors: Wen-Bin Ho, Hongda Zhao, Shaojiang Deng, Danny Ng, Lee R. Wright, Min Wu, Xiaoti Zhou, Michael P. Arend, Lee A. Flippin
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20150031696
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: May 28, 2014
    Publication date: January 29, 2015
    Applicant: FIBROGEN, INC.
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Cyanoisoquinoline compounds and methods of use thereof
    Patent number: 8759373
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: June 24, 2014
    Assignee: Fibrogen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
    Patent number: 8324405
    Abstract: The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: December 4, 2012
    Assignee: FibroGen, Inc.
    Inventors: Wen-bin Ho, Lee Wright, Shaojiang Deng, Eric Turtle, Lee A. Flippin
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20120178755
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 12, 2012
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Compounds and methods for their use
    Patent number: 8217043
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: July 10, 2012
    Assignee: Fibrogen, Inc.
    Inventors: Shaojiang Deng, Wen-Bin Ho, Lee A. Flippin
  • Cyanoisoquinoline Compounds and Methods of Use Thereof
    Publication number: 20110212959
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: March 7, 2011
    Publication date: September 1, 2011
    Inventors: Michael P. Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Cyanoisoquinoline compounds and methods of use thereof
    Patent number: 7928120
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: April 19, 2011
    Assignee: FibroGen, Inc.
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS
    Publication number: 20100331400
    Abstract: The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Application
    Filed: February 5, 2009
    Publication date: December 30, 2010
    Inventors: Wen-bin Ho, Lee Wright, Shaojiang Deng, Eric Turtle, Lee A. Flippin
  • Pyrrolo- and Thiazolo-pyridine compounds, and methods of use thereof
    Patent number: 7696223
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: April 13, 2010
    Assignee: FibroGen, Inc.
    Inventors: Shaojiang Deng, Min Wu, Eric D. Turtle, Wen-Bin Ho, Michael P. Arend, Heng Cheng, Lee A. Flippin
  • COMPOUNDS AND METHODS FOR THEIR USE
    Publication number: 20100047367
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
    Type: Application
    Filed: August 20, 2009
    Publication date: February 25, 2010
    Inventors: Shaojiang Deng, Wen-Bin Ho, Lee A. Flippin
  • PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF
    Publication number: 20080004309
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Application
    Filed: April 4, 2007
    Publication date: January 3, 2008
    Inventors: Shaojiang DENG, Min Wu, Eric Turtle, Wen-Bin Ho, Michael Arend, Heng Cheng, Lee Flippin
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20070298104
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: January 26, 2007
    Publication date: December 27, 2007
    Inventors: Michael Arend, Lee Flippin, Min Wu, Eric Turtle, Wen-Bin Ho, Shaojiang Deng