Patents by Inventor Shaojun FU

Shaojun FU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF VELPATASVIR AND DERIVATIVE THEREOF
    Publication number: 20210139493
    Abstract: The present invention relates to a preparation method for velpatasvir and a derivative thereof. Specifically, in the present invention, velpatasvir and the derivative thereof is prepared by means of an intermediate compound represented by the following formula (definitions of the groups are described in the specifications). By means of the method, byproducts are fewer, costs are low, and the method is applicable to industrial production of velpatasvir.
    Type: Application
    Filed: February 27, 2018
    Publication date: May 13, 2021
    Inventors: Shaojun FU, Chengjun HUANG, Yi REN, Wei LI
  • Ledipasvir crystal form and preparation method thereof
    Patent number: 10294219
    Abstract: The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 21, 2019
    Assignee: SHANGHAI FOREFRONT PHARMACEUTICAL CO., LTD.
    Inventors: Wei Li, Yi Ren, Chengjun Huang, Yanyan Zhu, Shaojun Fu, Gang Fu, Zhewen Wei
  • NOVEL LEDIPASVIR CRYSTAL FORM AND PREPARATION METHOD THEREOF
    Publication number: 20180194752
    Abstract: The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 12, 2018
    Inventors: Wei LI, Yi REN, Chengjun HUANG, Yanyan ZHU, Shaojun FU, Gang FU, Zhewen WEI
  • METHOD OF PREPARATION FOR LEDIPASVIR AND DERIVATIVE THEREOF, AND INTERMEDIATE COMPOUND FOR PREPARATION OF LEDIPASVIR
    Publication number: 20180079744
    Abstract: Methods of preparing Ledipasvir and derivatives thereof, and intermediate compounds used in the preparation of Ledipasvir are provided. Specifically, a method for preparing the compounds of formula 1 and a series of preparation methods of preparing Ledipasvir are provided. The methods described herein are simple and efficient, and have better application prospects.
    Type: Application
    Filed: March 2, 2016
    Publication date: March 22, 2018
    Inventors: Chengjun HUANG, Gang FU, Shaojun FU, Zhewen WEI, Wei LI, Xixuan ZHANG