Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.

Abstract: A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Abstract: The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLpro activity, and is useful in the preparation of a SARS-CoV-2 3CLpro inhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLpro inhibitors and anti-SARS-CoV-2 drugs.

Abstract: A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Abstract: Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; R5 is a hydrogen or halogen; and R6 is hydrogen, C1-4 alkane or C1-4 cycloalkane.

Abstract: This invention relates to a method of carbothermic process of magnesium production and co-production of calcium carbide, which is particularly suitable for carbothermic process of magnesium production with a mixture of magnesium oxide and calcium oxide as a raw material and carbon as a reducing agent. A mixed powder containing magnesium oxide, calcium oxide and a carbon reducing agent is prepared. The mixed powder is processed into a pelletized furnace feed material, which is placed into a reactor equipped with a heat source. With an absolute pressure P in the reactor being set within the range of 1000 Pa?P?atmospheric pressure or to a slightly positive pressure and a reaction temperature T within the range of 11 lg2P+71 lgP+1210° C.<T<98 lg2P-129 lgP+1300° C., a smelting reaction is run. Liquid magnesium is obtained through condensation by a condenser connected to the reactor, and after the smelting reaction has finished, calcium carbide is obtained within the reactor.

Abstract: A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Abstract: A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Abstract: The disclosure belongs to the technical field of surface coating, and particularly relates to a flux-cored welding wire, a preparation method and use thereof, a porous coating and a preparation method thereof. The disclosure provides a flux-cored welding wire, including a core wire and a sheath, where the core wire includes the following components by mass percentage: 15.0-30.0% of Cr, 1.5-2.5% of Si, 5.0-10.0% of Ni, 1.0-5.0% of TiH2, and Fe as balance; and the sheath is made of steel. Test results of examples show that, the porous coating obtained by supersonic arc spraying the flux-cored welding wire provided by the disclosure has a porosity of up to 46% and a coating adhesive strength of 45 MPa, which are desired.

Abstract: Provided herein is a molecular signature that delineates response to ibrutinib and its use in predicting responsiveness to ibrutinib for lymphoma patients, and in particular for mantle cell lymphoma patients. Also provided are methods of treating a patient that is predicted to be ibrutinib-resistant with an inhibitor of oxidative phosphorylation, a BH3-mimetic, a noncovalent BTK inhibitor, or a CAR-T therapy.

Abstract: This invention is a kind of electrooptic Q-switch element made of a single crystal and belongs to the application of crystal in electrooptic technology field. The invention consists of electrooptic Q-switch which is made of La3Ga5SiO14 or Nd:La3Ga5SiO14 or the other related crystal materials such as La3Ga5-xAlxSiO14, Sr3Ga2Ge4SiO14, Na2CaGe6O14, Ca3Ga2Ge4O14, La3Ga5.5Nb0.5O14 and La3Ga5.5Ta0.5O14 with the common shape or a specific shape containing Brewster angle as shown in figure. This kind of electrooptic Q-switch can be used in YAG laser and other laser. It overcomes the shortages of the commercial Q-switches, such as the high, un-adjustable, low stable half-wave voltage and great half-wave voltage variation with temperature. The advantage of this kind of electrooptic Q-switch is its low, adjustable, high stable half-wave voltage.

Abstract: The present invention provides an electrooptic Q-switch element made of a single crystal. The invention includes a langasite (LGS) single crystal and a reflection element located on one side of the langasite crystal along the light propagation direction. A light beam penetrates the LGS crystal along the main optical axis, is reflected by the reflection element, and passes through the LGS crystal again, so that the rotation angle of the polarization plane of the light originating from the optical activity is zero degrees. One advantage of the electrooptic Q-switch is its low, adjustable, high stable half-wave voltage. The invention can overcome the problems associated with current commercial Q-switches, such as high, non-adjustable, low stable half-wave voltage and great half-wave voltage variation with temperature.